diff --git a/dev-util/pixi/metadata.xml b/dev-util/pixi/metadata.xml
index 8d4e3d5944d6a..4c14558aee50d 100644
--- a/dev-util/pixi/metadata.xml
+++ b/dev-util/pixi/metadata.xml
@@ -8,4 +8,7 @@
 	<upstream>
 		<remote-id type="github">prefix-dev/pixi</remote-id>
 	</upstream>
+	<use>
+		<flag name="rustls">Use Rustls instead of OpenSSL.</flag>
+	</use>
 </pkgmetadata>
diff --git a/dev-util/pixi/pixi-0.45.0.ebuild b/dev-util/pixi/pixi-0.45.0.ebuild
index c56237d37eec0..48ca33f8f4896 100644
--- a/dev-util/pixi/pixi-0.45.0.ebuild
+++ b/dev-util/pixi/pixi-0.45.0.ebuild
@@ -81,12 +81,13 @@ LICENSE+="
 "
 SLOT="0"
 KEYWORDS="~amd64"
+IUSE="+rustls"
 
 RDEPEND="
 	app-arch/bzip2:=
 	app-arch/xz-utils:=
 	app-arch/zstd:=
-	dev-libs/openssl:=
+	!rustls? ( dev-libs/openssl:= )
 "
 
 src_prepare() {
@@ -103,7 +104,7 @@ src_prepare() {
 
 src_configure() {
 	local myfeatures=(
-		native-tls
+		$(usex rustls rustls-tls native-tls)
 	)
 	cargo_src_configure --no-default-features