diff --git a/sci-libs/hipSOLVER/Manifest b/sci-libs/hipSOLVER/Manifest
index 3a35fd3be1889..9a3383d70778c 100644
--- a/sci-libs/hipSOLVER/Manifest
+++ b/sci-libs/hipSOLVER/Manifest
@@ -3,3 +3,4 @@ DIST hipSOLVER-rocm-6.1.1.tar.gz 2553462 BLAKE2B 77731b876a7fe5f80f79e5af5128a84
 DIST hipSOLVER-rocm-6.3.2.tar.gz 2575541 BLAKE2B b61e50de293ef5b37e5296a194ce3ecef3fafa624345d1d0be1ef987db5bc15b9d8d8a5399faa5ab6745d2af9326c8d19b002411d143aa4f0b0bd4b47bae8070 SHA512 fb7de8eccd8691723b1ff86f1e9a7fe5f3ceccb77eb4fe6f2098987904cd874bb442d9b4728f980ed2c41f145e0f46fe6beae9a001305792ff50c81b5baffc7a
 DIST hipSOLVER-rocm-6.3.3.tar.gz 2573877 BLAKE2B 54d9736b63bfd314a155968737bf59c26685237e63e41a1500aa22841bb3c92a126645629dee8e9a87e0ee7a62035738dd85347a7dd0e4f05c7044755ef5e71e SHA512 d6213c1000e640bf29d96917df6f51f8f5fc30ec808d6473b7dd159f9ce160535170cec0f769c3749934e1896b9d3fcc1df21d5cda27b4d233e6a8c50e23c114
 DIST hipSOLVER-rocm-6.4.1.tar.gz 2577495 BLAKE2B 1a7f86aba2eff38166bfd274649243b42400649cf0020a5e2fe543bc7cd41450212b51b6fe3e10a986d1cb62e0f9c70cfdfbe281ab9399eae2777c7b4ce0c378 SHA512 e913f512d644f9a9f15c3534962ac3ca473a81b0fc2a62d0b18aea13dea5c01fda2a3d60d79974082c498c6066ae539bb8a6b878f1e014d9988817461d8b6a38
+DIST hipSOLVER-rocm-6.4.3.tar.gz 2580341 BLAKE2B 28f40af2887befece27186aba11d6e777ae705225e4daa5b7f4599cd7bc719e908481840b3d41480b00b2945ab51e276a1962bc5fe6f44ad873eac2871f157cf SHA512 6cd8e4e0cfb0963325092ff3d8341fd630dfe3f4dbc0f15a625aa23c3a43225fc288523548cec3db0c698d765c5c37bdf22225235c2eefab6b8ee18bb0ffdffd
diff --git a/sci-libs/hipSOLVER/hipSOLVER-6.4.3.ebuild b/sci-libs/hipSOLVER/hipSOLVER-6.4.3.ebuild
new file mode 100644
index 0000000000000..13bd41f152bb8
--- /dev/null
+++ b/sci-libs/hipSOLVER/hipSOLVER-6.4.3.ebuild
@@ -0,0 +1,49 @@
+# Copyright 1999-2025 Gentoo Authors
+# Distributed under the terms of the GNU General Public License v2
+
+EAPI=8
+
+ROCM_VERSION=${PV}
+
+inherit cmake rocm
+
+DESCRIPTION="CU / ROCM agnostic marshalling library for LAPACK routines on the GPU"
+HOMEPAGE="https://github.com/ROCm/hipSOLVER"
+SRC_URI="https://github.com/ROCm/hipSOLVER/archive/refs/tags/rocm-${PV}.tar.gz -> hipSOLVER-rocm-${PV}.tar.gz"
+S="${WORKDIR}/hipSOLVER-rocm-${PV}"
+
+REQUIRED_USE="${ROCM_REQUIRED_USE}"
+
+LICENSE="MIT"
+SLOT="0/$(ver_cut 1-2)"
+KEYWORDS="~amd64"
+IUSE="sparse"
+
+RESTRICT="test"
+
+RDEPEND="
+	dev-util/hip:${SLOT}
+	sci-libs/rocSOLVER:${SLOT}
+	sparse? (
+		sci-libs/suitesparseconfig
+		sci-libs/cholmod
+	)
+"
+DEPEND="${RDEPEND}"
+
+PATCHES=(
+	"${FILESDIR}"/${PN}-6.4.1-find-cholmod.patch
+)
+
+src_configure() {
+	rocm_use_hipcc
+
+	local mycmakeargs=(
+		-DGPU_TARGETS="$(get_amdgpu_flags)"
+		-DBUILD_FILE_REORG_BACKWARD_COMPATIBILITY=OFF
+		-DROCM_SYMLINK_LIBS=OFF
+		-DBUILD_WITH_SPARSE=$(usex sparse ON OFF)
+	)
+
+	cmake_src_configure
+}