diff --git a/sys-devel/clang/clang-19.1.0.ebuild b/sys-devel/clang/clang-19.1.0.ebuild
index 54dae879d7679..2d7aae85f1700 100644
--- a/sys-devel/clang/clang-19.1.0.ebuild
+++ b/sys-devel/clang/clang-19.1.0.ebuild
@@ -331,12 +331,6 @@ multilib_src_configure() {
 		)
 	fi
 
-	if [[ -n ${EPREFIX} ]]; then
-		mycmakeargs+=(
-			-DGCC_INSTALL_PREFIX="${EPREFIX}/usr"
-		)
-	fi
-
 	if tc-is-cross-compiler; then
 		has_version -b sys-devel/clang:${LLVM_MAJOR} ||
 			die "sys-devel/clang:${LLVM_MAJOR} is required on the build host."
diff --git a/sys-devel/clang/clang-20.0.0.9999.ebuild b/sys-devel/clang/clang-20.0.0.9999.ebuild
index 6ba764b5fc978..cad701817a80b 100644
--- a/sys-devel/clang/clang-20.0.0.9999.ebuild
+++ b/sys-devel/clang/clang-20.0.0.9999.ebuild
@@ -329,12 +329,6 @@ multilib_src_configure() {
 		)
 	fi
 
-	if [[ -n ${EPREFIX} ]]; then
-		mycmakeargs+=(
-			-DGCC_INSTALL_PREFIX="${EPREFIX}/usr"
-		)
-	fi
-
 	if tc-is-cross-compiler; then
 		has_version -b sys-devel/clang:${LLVM_MAJOR} ||
 			die "sys-devel/clang:${LLVM_MAJOR} is required on the build host."
diff --git a/sys-devel/clang/clang-20.0.0_pre20240917.ebuild b/sys-devel/clang/clang-20.0.0_pre20240917.ebuild
index 857f7b1ed5a2e..3fc2fa1547703 100644
--- a/sys-devel/clang/clang-20.0.0_pre20240917.ebuild
+++ b/sys-devel/clang/clang-20.0.0_pre20240917.ebuild
@@ -331,12 +331,6 @@ multilib_src_configure() {
 		)
 	fi
 
-	if [[ -n ${EPREFIX} ]]; then
-		mycmakeargs+=(
-			-DGCC_INSTALL_PREFIX="${EPREFIX}/usr"
-		)
-	fi
-
 	if tc-is-cross-compiler; then
 		has_version -b sys-devel/clang:${LLVM_MAJOR} ||
 			die "sys-devel/clang:${LLVM_MAJOR} is required on the build host."
diff --git a/sys-devel/clang/clang-20.0.0_pre20240924.ebuild b/sys-devel/clang/clang-20.0.0_pre20240924.ebuild
index 76e65b231fc42..e0aabafeccdcc 100644
--- a/sys-devel/clang/clang-20.0.0_pre20240924.ebuild
+++ b/sys-devel/clang/clang-20.0.0_pre20240924.ebuild
@@ -332,12 +332,6 @@ multilib_src_configure() {
 		)
 	fi
 
-	if [[ -n ${EPREFIX} ]]; then
-		mycmakeargs+=(
-			-DGCC_INSTALL_PREFIX="${EPREFIX}/usr"
-		)
-	fi
-
 	if tc-is-cross-compiler; then
 		has_version -b sys-devel/clang:${LLVM_MAJOR} ||
 			die "sys-devel/clang:${LLVM_MAJOR} is required on the build host."