diff --git a/dev-python/qiskit/Manifest b/dev-python/qiskit/Manifest
index 15bc0efb9af40..888926f5eb998 100644
--- a/dev-python/qiskit/Manifest
+++ b/dev-python/qiskit/Manifest
@@ -1,2 +1,3 @@
 DIST qiskit-2.1.1-crates.tar.xz 15412164 BLAKE2B 24a65f0ec256c2f848102c039106ef0fecb33be0fb00494f0ca707285e224ade0efd1a4a6a557dc5dd7d2224924e2b94a4a4585d8a9030a310f0f1a999ac0713 SHA512 779aca54c2da20f2558f5fab2de0ee22c861f2edd88dea17e79d1f7f796eda9612bcf45a08a0647032049e67e9c467236b493cb02efcf199e2951109c316e53a
 DIST qiskit-2.1.1.gh.tar.gz 7095152 BLAKE2B fa611f4a5e772ba66bc58bc2832f6779dee514b1956adfea03dc92f7745f607e0f7654d018f3b501f9f1ce740875c60b14c2d3c92142240ce324a6b91daa8f6a SHA512 7eade06c30c264979ceaffb2cd948dfea358973351165a66472150ab8e6bfc73e6c2c5107b4024352efcc01bea9beea897ac4fbc389e81df79e07e54f2673851
+DIST qiskit-2.1.2.gh.tar.gz 7100760 BLAKE2B 01f5789f20d1c73e73000ec87579981380d201b4d614dbfd7974d603c031de2a567e42c41f4552442805eb38b729784442a1e04e36054ba0c0a44a68b7410ad4 SHA512 a2e435f2523f538c922c868bf1fb303143f2efe4f3f70fe286d25fe467c454888f4fe7dc81b94e30e134e15446c6f3364a9ee932b5229952cb178e5db019ac1d
diff --git a/dev-python/qiskit/qiskit-2.1.2.ebuild b/dev-python/qiskit/qiskit-2.1.2.ebuild
new file mode 100644
index 0000000000000..fcd271e1e8bbf
--- /dev/null
+++ b/dev-python/qiskit/qiskit-2.1.2.ebuild
@@ -0,0 +1,109 @@
+# Copyright 2022-2025 Gentoo Authors
+# Distributed under the terms of the GNU General Public License v2
+
+EAPI=8
+
+DISTUTILS_EXT=1
+DISTUTILS_USE_PEP517=setuptools
+PYTHON_COMPAT=( python3_{11..13} )
+
+RUST_MIN_VER="1.81.0"
+
+inherit cargo distutils-r1
+
+MY_P=${P/_}
+CRATE_PV=2.1.1
+DESCRIPTION="An open-source SDK for working with quantum computers"
+HOMEPAGE="
+	https://github.com/Qiskit/qiskit/
+	https://pypi.org/project/qiskit/
+"
+SRC_URI="
+	https://github.com/Qiskit/qiskit/archive/${PV/_}.tar.gz
+		-> ${MY_P}.gh.tar.gz
+	${CARGO_CRATE_URIS}
+	https://github.com/gentoo-crate-dist/qiskit/releases/download/${CRATE_PV/_}/${PN}-${CRATE_PV}-crates.tar.xz
+"
+S=${WORKDIR}/${MY_P}
+
+LICENSE="Apache-2.0"
+# Dependent crate licenses
+LICENSE+="
+	Apache-2.0 Apache-2.0-with-LLVM-exceptions BSD-2 MIT MPL-2.0
+	Unicode-3.0 ZLIB
+"
+SLOT="0"
+KEYWORDS="~amd64"
+IUSE="+visualization"
+
+RDEPEND="
+	>=dev-python/dill-0.3[${PYTHON_USEDEP}]
+	>=dev-python/numpy-1.17[${PYTHON_USEDEP}]
+	>=dev-python/python-constraint-1.4[${PYTHON_USEDEP}]
+	>=dev-python/rustworkx-0.15.0[${PYTHON_USEDEP}]
+	>=dev-python/scipy-1.5[${PYTHON_USEDEP}]
+	>=dev-python/stevedore-3.0.0[${PYTHON_USEDEP}]
+	visualization? (
+		>=dev-python/matplotlib-3.3[${PYTHON_USEDEP}]
+		dev-python/pydot[${PYTHON_USEDEP}]
+		>=dev-python/pillow-4.2.1[${PYTHON_USEDEP}]
+		>=dev-python/pylatexenc-1.4[${PYTHON_USEDEP}]
+		>=dev-python/seaborn-0.9.0[${PYTHON_USEDEP}]
+		>=dev-python/symengine-0.11.0[${PYTHON_USEDEP}]
+		>=dev-python/sympy-1.3[${PYTHON_USEDEP}]
+	)
+"
+BDEPEND="
+	>=dev-python/cython-0.27.1[${PYTHON_USEDEP}]
+	test? (
+		app-text/poppler[png]
+		>=dev-python/ddt-1.4.4[${PYTHON_USEDEP}]
+		>=dev-python/networkx-2.2[${PYTHON_USEDEP}]
+		>=dev-python/qiskit-aer-0.14[${PYTHON_USEDEP}]
+		>=dev-python/scikit-learn-0.20.0[${PYTHON_USEDEP}]
+	)
+"
+
+# Files built without CFLAGS/LDFLAGS, acceptable for rust
+QA_FLAGS_IGNORED="
+	usr/lib.*/py.*/site-packages/qiskit/_accelerate.*.so
+	usr/lib.*/py.*/site-packages/qiskit/_qasm2.*.so
+"
+
+EPYTEST_PLUGINS=( hypothesis )
+EPYTEST_XDIST=1
+distutils_enable_tests pytest
+
+src_prepare() {
+	distutils-r1_src_prepare
+
+	# strip forcing -Werror from tests that also leaks to other packages
+	sed -i -e '/filterwarnings.*error/d' test/utils/base.py || die
+}
+
+python_test() {
+	local EPYTEST_DESELECT=(
+		# TODO
+		test/python/circuit/test_equivalence.py::TestEquivalenceLibraryVisualization::test_equivalence_draw
+		test/python/transpiler/test_unitary_synthesis_plugin.py::TestUnitarySynthesisPlugin
+		test/python/visualization/test_dag_drawer.py::TestDagDrawer::test_dag_drawer_no_register
+		# tiny image differences, sigh
+		test/python/visualization/test_gate_map.py::TestGateMap::test_plot_error_map_over_100_qubit
+		# TODO: failures from dill
+		test/python/circuit/test_parameters.py::TestParameters::test_transpiling_multiple_parameterized_circuits
+		test/python/compiler/test_transpiler.py::TestTranspile::test_delay_converts_expr_to_dt
+		test/python/compiler/test_transpiler.py::TestTranspile::test_transpile_two
+		test/python/transpiler/test_naming_transpiled_circuits.py::TestNamingTranspiledCircuits::test_multiple_circuits_name_list
+	)
+
+	local EPYTEST_IGNORE=(
+		# Breaks xdist
+		test/python/qasm2/test_parse_errors.py
+		test/python/transpiler/test_preset_passmanagers.py
+	)
+
+	rm -rf qiskit || die
+	# Run the Python test suite rather than everything under test/ which
+	# includes the 'randomized' suite. Upstream run that in a separate CI job.
+	epytest test/python
+}