diff --git a/dev-python/pyicu/pyicu-2.0.2.ebuild b/dev-python/pyicu/pyicu-2.0.2.ebuild
index 1e6ff018f9863..4dc247fee2d4b 100644
--- a/dev-python/pyicu/pyicu-2.0.2.ebuild
+++ b/dev-python/pyicu/pyicu-2.0.2.ebuild
@@ -31,5 +31,10 @@ S="${WORKDIR}/${MY_P}"
 DOCS=(CHANGES CREDITS README.md)
 
 python_test() {
-	esetup.py test
+	if [[ ${EPYTHON} == python2* ]]; then
+		# See Bug #644226
+		ewarn "Skipping tests for ${EPYTHON} because they are known to fail"
+	else
+		esetup.py test
+	fi
 }