diff --git a/profiles/package.mask b/profiles/package.mask
index 4ce5cb8227b3a..055987ef3d8fe 100644
--- a/profiles/package.mask
+++ b/profiles/package.mask
@@ -29,6 +29,10 @@
 
 #--- END OF EXAMPLES ---
 
+# Jeroen Roovers <jer@gentoo.org> (19 Jan 2018)
+# Breaks net-libs/nodejs (bug #645018)
+=dev-libs/libuv-1.19.0
+
 # Patrice Clement <monsieurp@gentoo.org> (18 Jan 2018)
 # mpv-0.28.0 requires changes currently only available in ffmpeg-9999.
 =media-video/mpv-0.28.0