diff --git a/dev-python/rpy2-rinterface/Manifest b/dev-python/rpy2-rinterface/Manifest
new file mode 100644
index 0000000000000..3ad24db2e8613
--- /dev/null
+++ b/dev-python/rpy2-rinterface/Manifest
@@ -0,0 +1 @@
+DIST rpy2_rinterface-3.6.3.tar.gz 79406 BLAKE2B 188c35f2498685079f674199fc14f89fbbb1d752b933b109e44a5c570db99f8d2c871a1dbd45628029e8471818aeff14f72ea98c05a20657155a93df6dd6f426 SHA512 bdfe6ddc7e0aa54a94566c2006a87f08ed8f02239938039a7cf1f6b6cf5eaed158453adc5ccf9690333d8478058b40c35a498ea845e744db91293033bda1138a
diff --git a/dev-python/rpy2-rinterface/metadata.xml b/dev-python/rpy2-rinterface/metadata.xml
new file mode 100644
index 0000000000000..30bb3165d64ca
--- /dev/null
+++ b/dev-python/rpy2-rinterface/metadata.xml
@@ -0,0 +1,12 @@
+<?xml version="1.0" encoding="UTF-8"?>
+<!DOCTYPE pkgmetadata SYSTEM "https://www.gentoo.org/dtd/metadata.dtd">
+<pkgmetadata>
+  <maintainer type="project">
+    <email>sci@gentoo.org</email>
+    <name>Gentoo Science Project</name>
+  </maintainer>
+  <upstream>
+    <remote-id type="github">rpy2/rpy2</remote-id>
+    <remote-id type="pypi">rpy2-rinterface</remote-id>
+  </upstream>
+</pkgmetadata>
diff --git a/dev-python/rpy2-rinterface/rpy2-rinterface-3.6.3.ebuild b/dev-python/rpy2-rinterface/rpy2-rinterface-3.6.3.ebuild
new file mode 100644
index 0000000000000..ee2f01df33bb5
--- /dev/null
+++ b/dev-python/rpy2-rinterface/rpy2-rinterface-3.6.3.ebuild
@@ -0,0 +1,34 @@
+# Copyright 2025 Gentoo Authors
+# Distributed under the terms of the GNU General Public License v2
+
+EAPI=8
+
+DISTUTILS_EXT=1
+DISTUTILS_USE_PEP517=setuptools
+PYTHON_COMPAT=( python3_{11..14} )
+
+inherit distutils-r1 pypi
+
+DESCRIPTION="Low-level interface from Python to the R"
+HOMEPAGE="
+	https://rpy2.github.io/
+	https://github.com/rpy2/rpy2/
+	https://pypi.org/project/rpy2-rinterface/
+"
+
+LICENSE="GPL-2+"
+SLOT="0"
+KEYWORDS="~amd64"
+
+RDEPEND="
+	!<dev-python/rpy2-3.6.0
+	>=dev-lang/R-4.0
+	>=dev-python/cffi-1.15.1[${PYTHON_USEDEP}]
+"
+BDEPEND="
+	>=dev-python/cffi-1.15.1[${PYTHON_USEDEP}]
+	dev-python/wheel[${PYTHON_USEDEP}]
+"
+
+EPYTEST_PLUGINS=()
+distutils_enable_tests pytest