diff --git a/sci-libs/hipCUB/Manifest b/sci-libs/hipCUB/Manifest
index 49cc0060ff7cf..6c8dae2aacb21 100644
--- a/sci-libs/hipCUB/Manifest
+++ b/sci-libs/hipCUB/Manifest
@@ -3,3 +3,4 @@ DIST hipCUB-6.1.1.tar.gz 343181 BLAKE2B 3943278597c5e9d41c225ad86c3cdcc113f35cf1
 DIST hipCUB-6.3.2.tar.gz 387546 BLAKE2B b0d4d487fc1f799e10cd684255fe4bb31ed7329d0ea628c818df560d506aa2b4e5bdb08b007aab9ee95492a3fecf6f559c5c9724df15fe7da86d9aed84951c6b SHA512 735610735e4584ded05b30d99ae9042d3ccd4590689fc2c415eb45fb2fd0d7ab431704709bdd066341ec10284ca0f4c1ad108c188f95949ce962b6a75eb57e19
 DIST hipCUB-6.3.3.tar.gz 387580 BLAKE2B e0b605835be2b685c1cfa099a807e30fa061af8b14bafa1167c8249383230761a0d08532c831d3cb015e8e1b58119899d3cb7330990ca046045ea40058ee03e5 SHA512 2ec96088d34edeff48f8ee103a619f2ca7c741dcb020a3d1833a00e2072510790a563e98662aef7aa2a348034f3c8169ee39dcc61ab95202c734901ba53dfa4b
 DIST hipCUB-6.4.1.tar.gz 420053 BLAKE2B c5fde544499b8ebb16ed4a1c51621255120e1d672a9ddab3eab5019f759fc5345b2e2f363486c6956bd57a502215afa45208d849e2c4424366d28cdfac6548dd SHA512 2cbbf74e060dde3b6e354f38611079407c0cb6d9954af5402be7ee8b77667f7ccb08be676f9f50b5ce1a480e77da6302d852e8c4af8885ee924d79da39179c47
+DIST hipCUB-6.4.3.tar.gz 419173 BLAKE2B 7e1e707210191eee00aab01f8768a272f1fb5c35bb9e0635fe32ad50f4a8b56634d5f097f5eb2d1d5625f30f62450368a25a95ac2ba8fe85da2effd8efd669c9 SHA512 fb8018cf6200a468601149b6508b50944a27c3f7562012fef39e3a0ca13ed5ff597b1a3ad9e02273b70020ebd19ed10322e46d324f09fcf32a4f363e0ba72036
diff --git a/sci-libs/hipCUB/hipCUB-6.4.3.ebuild b/sci-libs/hipCUB/hipCUB-6.4.3.ebuild
new file mode 100644
index 0000000000000..92d497cbda10e
--- /dev/null
+++ b/sci-libs/hipCUB/hipCUB-6.4.3.ebuild
@@ -0,0 +1,62 @@
+# Copyright 1999-2025 Gentoo Authors
+# Distributed under the terms of the GNU General Public License v2
+
+EAPI=8
+
+ROCM_VERSION=${PV}
+
+inherit cmake rocm
+
+DESCRIPTION="Wrapper of rocPRIM or CUB for GPU parallel primitives"
+HOMEPAGE="https://github.com/ROCm/hipCUB"
+SRC_URI="https://github.com/ROCm/hipCUB/archive/rocm-${PV}.tar.gz -> hipCUB-${PV}.tar.gz"
+S="${WORKDIR}/hipCUB-rocm-${PV}"
+
+LICENSE="BSD"
+SLOT="0/$(ver_cut 1-2)"
+KEYWORDS="~amd64"
+IUSE="benchmark test"
+REQUIRED_USE="
+	benchmark? ( ${ROCM_REQUIRED_USE} )
+	test? ( ${ROCM_REQUIRED_USE} )
+"
+RESTRICT="!test? ( test )"
+
+RDEPEND="dev-util/hip:${SLOT}
+	sci-libs/rocPRIM:${SLOT}
+	benchmark? ( dev-cpp/benchmark )
+	test? ( dev-cpp/gtest )
+"
+DEPEND="${RDEPEND}"
+
+PATCHES=(
+	"${FILESDIR}"/${PN}-6.4.1-no-tests-install.patch
+)
+
+src_prepare() {
+	sed -e "s:set(ROCM_INSTALL_LIBDIR lib):set(ROCM_INSTALL_LIBDIR $(get_libdir)):" \
+		-i cmake/ROCMExportTargetsHeaderOnly.cmake || die
+
+	cmake_src_prepare
+}
+
+src_configure() {
+	rocm_use_hipcc
+
+	local mycmakeargs=(
+		-DGPU_TARGETS="$(get_amdgpu_flags)"
+		-DBUILD_TEST=$(usex test ON OFF)
+		-DBUILD_BENCHMARK=$(usex benchmark ON OFF)
+		-DBUILD_FILE_REORG_BACKWARD_COMPATIBILITY=OFF
+	)
+
+	cmake_src_configure
+}
+
+src_test() {
+	check_amdgpu
+	# Expected time on gfx1100 (-j32) is 85s
+	# HipcubDeviceHistogramMultiEven/0.MultiEven in 6.4.1 has bad array access (probably fixed in the future release)
+	local CMAKE_SKIP_TESTS=(hipcub.DeviceHistogram)
+	cmake_src_test
+}