diff --git a/sci-biology/cufflinks/cufflinks-2.2.1-r2.ebuild b/sci-biology/cufflinks/cufflinks-2.2.1-r2.ebuild
index 745baffad99df..3892e03e23b2d 100644
--- a/sci-biology/cufflinks/cufflinks-2.2.1-r2.ebuild
+++ b/sci-biology/cufflinks/cufflinks-2.2.1-r2.ebuild
@@ -1,4 +1,4 @@
-# Copyright 1999-2017 Gentoo Foundation
+# Copyright 1999-2018 Gentoo Foundation
 # Distributed under the terms of the GNU General Public License v2
 
 EAPI=6
@@ -33,6 +33,7 @@ PATCHES=(
 	"${FILESDIR}"/${P}-boost-1.65-tr1-removal.patch
 	"${FILESDIR}"/${P}-gcc7.patch
 	"${FILESDIR}"/${P}-format-security.patch
+	"${FILESDIR}"/${P}-gcc5-make_shared.patch
 )
 
 src_prepare() {
diff --git a/sci-biology/cufflinks/files/cufflinks-2.2.1-gcc5-make_shared.patch b/sci-biology/cufflinks/files/cufflinks-2.2.1-gcc5-make_shared.patch
new file mode 100644
index 0000000000000..67a28df10249c
--- /dev/null
+++ b/sci-biology/cufflinks/files/cufflinks-2.2.1-gcc5-make_shared.patch
@@ -0,0 +1,11 @@
+--- a/src/differential.cpp
++++ b/src/differential.cpp
+@@ -575,7 +575,7 @@
+     boost::mutex::scoped_lock lock(meta_data_lock);
+ #endif
+     pair<SampleDiffMetaDataTable::iterator, bool> p;
+-    p = meta_data_table.insert(make_pair(description, new SampleDifferenceMetaData()));
++    p = meta_data_table.insert(make_pair(description, boost::make_shared<SampleDifferenceMetaData>()));
+     return p.first->second;
+ }
+