diff --git a/sci-libs/cfitsio/Manifest b/sci-libs/cfitsio/Manifest
index 645f49c067d54..abce05c33554e 100644
--- a/sci-libs/cfitsio/Manifest
+++ b/sci-libs/cfitsio/Manifest
@@ -1,2 +1,3 @@
 DIST cfitsio-4.2.0.tar.gz 4356372 BLAKE2B 7f5e695a56105866b2457e0f1c2d74bfb2aa86bc53e4eeb39aa9b8e79b278e1184a610422bf43c341a9f3159a93b980bab1ec9084475189b08dfa080b59ec2af SHA512 41b51653370874f50a7a9fe7d5f61577a979ab9d146b8249afa407d3858cb4dce0581eba23093972b66f7d1042b9693b98ad9130ec67b3b44e94005e72d60853
 DIST cfitsio-4.4.0.tar.gz 4278372 BLAKE2B 883a88b08ecddb756a479c361fd0dc4741cffd9b82f311d3cde3f4bede2ac3cb68c8597a5d1cc1350f14b2b145a628fa0ec90754284c0cd4ec1472cb370af01e SHA512 9358b1ed94fdc456cf8c0ddcb346c08f6bc97ee862c31366f3fae2d1be8d5278ffc79da01e41ceebf67ebc831f58bce3551e087c883bbf6b396133110d74b076
+DIST cfitsio-4.4.1.tar.gz 4308170 BLAKE2B 237a2f899b39a01ed73e3e41b420874c7654faf1f93e3c3b3454d2001a472f64b1c44fa2c88598ea21e3a8d60a1dcb76aa3001fee1e4443f91bcd565ce605a4f SHA512 a49e4e09a2e5f6e0ae823a68f02b3f6285cf3e0af66c9a1f8dadcd2867fa83c17fd27e446e8e5af9374ff2dc7b7a18334663ce977a1691c4ed4ced14d33232b7
diff --git a/sci-libs/cfitsio/cfitsio-4.4.1.ebuild b/sci-libs/cfitsio/cfitsio-4.4.1.ebuild
new file mode 100644
index 0000000000000..a27f43704caba
--- /dev/null
+++ b/sci-libs/cfitsio/cfitsio-4.4.1.ebuild
@@ -0,0 +1,77 @@
+# Copyright 1999-2024 Gentoo Authors
+# Distributed under the terms of the GNU General Public License v2
+
+EAPI=8
+
+inherit cmake-multilib fortran-2
+
+DESCRIPTION="C and Fortran library for manipulating FITS files"
+HOMEPAGE="https://heasarc.gsfc.nasa.gov/docs/software/fitsio/fitsio.html"
+SRC_URI="https://heasarc.gsfc.nasa.gov/FTP/software/fitsio/c/${P}.tar.gz"
+
+LICENSE="ISC"
+SLOT="0/10"
+KEYWORDS="~alpha ~amd64 ~hppa ~ppc ~ppc64 ~riscv ~sparc ~x86 ~amd64-linux ~x86-linux ~ppc-macos ~x64-macos"
+IUSE="bzip2 curl test threads tools cpu_flags_x86_sse2 cpu_flags_x86_ssse3"
+RESTRICT="!test? ( test )"
+
+BDEPEND="
+	app-alternatives/yacc
+	app-alternatives/lex
+"
+RDEPEND="
+	sys-libs/zlib[${MULTILIB_USEDEP}]
+	bzip2? ( app-arch/bzip2[${MULTILIB_USEDEP}] )
+	curl? ( net-misc/curl[${MULTILIB_USEDEP}] )
+"
+# Bug #803350
+DEPEND="
+	${RDEPEND}
+	<dev-lang/cfortran-20110621
+"
+
+pkg_setup() {
+	fortran-2_pkg_setup
+}
+
+src_prepare() {
+	cmake_src_prepare
+
+	if ! grep -q 'CFITSIO_SONAME,10' configure.in; then
+		die "Update subslot!"
+	fi
+
+	# fix libdir & sync SONAME to configure.in
+	sed -e 's:lib/:${CMAKE_INSTALL_LIBDIR}/:' \
+		-e "/SOVERSION/s:VERSION :VERSION ${SLOT#0/}.:" \
+		-e "s:SOVERSION :SOVERSION ${SLOT#0/}.:" \
+		-i CMakeLists.txt || die
+
+	# Avoid internal cfortran
+	rm cfortran.h || die
+}
+
+multilib_src_configure() {
+	local libdir=$(get_libdir)
+	local mycmakeargs=(
+		# used for .pc file
+		-DLIB_SUFFIX=${libdir#lib}
+
+		-DUSE_BZIP2=$(usex bzip2)
+		-DUSE_CURL=$(usex curl)
+		-DUSE_PTHREADS=$(usex threads)
+		-DUSE_SSE2=$(usex cpu_flags_x86_sse2)
+		-DUSE_SSSE3=$(usex cpu_flags_x86_ssse3)
+
+		-DTESTS=$(usex test)
+		-DUTILS=$(multilib_native_usex tools)
+	)
+	cmake_src_configure
+}
+
+multilib_src_install_all() {
+	dodoc README.md docs/changes.txt docs/*.pdf
+
+	docinto examples
+	dodoc utilities/{cookbook.{c,f},testprog.c,testf77.f,speed.c,smem.c}
+}