diff --git a/dev-util/mingw64-runtime/mingw64-runtime-10.0.0-r1.ebuild b/dev-util/mingw64-runtime/mingw64-runtime-10.0.0-r1.ebuild
index ffbdbd5e4dddf..dbbdbd2de31cd 100644
--- a/dev-util/mingw64-runtime/mingw64-runtime-10.0.0-r1.ebuild
+++ b/dev-util/mingw64-runtime/mingw64-runtime-10.0.0-r1.ebuild
@@ -1,4 +1,4 @@
-# Copyright 1999-2022 Gentoo Authors
+# Copyright 1999-2023 Gentoo Authors
 # Distributed under the terms of the GNU General Public License v2
 
 EAPI=8
@@ -70,6 +70,13 @@ src_configure() {
 		filter-flags '-mfunction-return=thunk*' #878849
 	fi
 	local CHOST=${CTARGET}
+
+	# -mavx with mingw-gcc has a history of obscure issues and
+	# disabling is seen as safer, e.g. `WINEARCH=win32 winecfg`
+	# crashes with -march=skylake >=wine-8.10, similar issues with
+	# znver4: https://gcc.gnu.org/bugzilla/show_bug.cgi?id=110273
+	tc-is-gcc && append-flags -mno-avx
+
 	strip-unsupported-flags
 
 	# Normally mingw64 does not use dynamic linker.
diff --git a/dev-util/mingw64-runtime/mingw64-runtime-11.0.0.ebuild b/dev-util/mingw64-runtime/mingw64-runtime-11.0.0.ebuild
index e9b21a93f78c5..5e0b60934d209 100644
--- a/dev-util/mingw64-runtime/mingw64-runtime-11.0.0.ebuild
+++ b/dev-util/mingw64-runtime/mingw64-runtime-11.0.0.ebuild
@@ -65,6 +65,13 @@ src_configure() {
 		filter-flags '-mfunction-return=thunk*' #878849
 	fi
 	local CHOST=${CTARGET}
+
+	# -mavx with mingw-gcc has a history of obscure issues and
+	# disabling is seen as safer, e.g. `WINEARCH=win32 winecfg`
+	# crashes with -march=skylake >=wine-8.10, similar issues with
+	# znver4: https://gcc.gnu.org/bugzilla/show_bug.cgi?id=110273
+	tc-is-gcc && append-flags -mno-avx
+
 	strip-unsupported-flags
 
 	# Normally mingw64 does not use dynamic linker, but at configure time it