diff --git a/profiles/prefix/use.stable.mask b/profiles/prefix/use.stable.mask
index 545d346185292..2d6679d795e62 100644
--- a/profiles/prefix/use.stable.mask
+++ b/profiles/prefix/use.stable.mask
@@ -5,3 +5,4 @@
 # Re-enable python-3.5, we are fully ~arch, so avoid problems with
 # Portage like bug #572502
 -python_targets_python3_5
+-python_single_target_python3_5