diff --git a/dev-python/PyQt6/PyQt6-6.4.2.ebuild b/dev-python/PyQt6/PyQt6-6.4.2.ebuild
index cf5de2a490c4b..4e892b399454a 100644
--- a/dev-python/PyQt6/PyQt6-6.4.2.ebuild
+++ b/dev-python/PyQt6/PyQt6-6.4.2.ebuild
@@ -77,8 +77,7 @@ src_prepare() {
 	PATH=${T}/cxx:${PATH}
 }
 
-src_configure() {
-	append-cppflags $(usex debug -{U,D}NDEBUG) # not set by eclass "yet"
+python_configure_all() {
 	append-cxxflags -std=c++17 # for old gcc / clang that use <17 (bug #892331)
 	append-cxxflags ${CPPFLAGS} # respect CPPFLAGS
 
diff --git a/dev-python/PyQt6/PyQt6-6.5.0.ebuild b/dev-python/PyQt6/PyQt6-6.5.0.ebuild
index a731a68b3575c..36a47c507bf3e 100644
--- a/dev-python/PyQt6/PyQt6-6.5.0.ebuild
+++ b/dev-python/PyQt6/PyQt6-6.5.0.ebuild
@@ -78,8 +78,7 @@ src_prepare() {
 	PATH=${T}/cxx:${PATH}
 }
 
-src_configure() {
-	append-cppflags $(usex debug -{U,D}NDEBUG) # not set by eclass "yet"
+python_configure_all() {
 	append-cxxflags -std=c++17 # for old gcc / clang that use <17 (bug #892331)
 	append-cxxflags ${CPPFLAGS} # respect CPPFLAGS