diff --git a/sci-chemistry/avogadro2/Manifest b/sci-chemistry/avogadro2/Manifest
index acb037d6ace6c..f64fa825c3472 100644
--- a/sci-chemistry/avogadro2/Manifest
+++ b/sci-chemistry/avogadro2/Manifest
@@ -2,3 +2,5 @@ DIST avogadro2-1.102.1-i18n.tar.gz 1450971 BLAKE2B 187cd08f1ae674776bb9d72ef70a1
 DIST avogadro2-1.102.1.tar.gz 3832563 BLAKE2B 81200635b377825afc724d26e025953ff8e1e90e3230ef1b13df86827cfdd754fc6a3833d0bcd5c165869a7e8a20f2590b20bd51c2abe4c3e9a0a6527307500b SHA512 40492ba4b5ac998e7e9e0fea36b18a9e43ec20d75a176806a4b18eafca17d4ea55d3969978e8cdc03a6825e692acc4707c8b8494ba3e38592f6adc7d32034761
 DIST avogadro2-1.103.0-i18n.tar.gz 1496239 BLAKE2B 722e43c43854640a85a80fcd7e2cbf9d4d5929cb7e431eb7d7739014f878701106677343887f34fbb7d8e0c21e948d5efe26447bfd7a6c97f95552dfe8b0efd7 SHA512 8c767a9415be04cb19691ae533f13c210fdf1cbfe0cdf914271d024bfa90960b3edbc2d5a9230c0504c3004b6eea7a4f5b0cd40fe83b53dda1c5cc9d079221f6
 DIST avogadro2-1.103.0.tar.gz 3848364 BLAKE2B c17b9ef43c4b3980b0083c91d9b60995d801c20033ab55d25a0bcc579b59106aa74423818fdf04921ea55a3fd3acfdfd849c4851b0b922615ebf50408ad59f44 SHA512 1298e929a0cd415ecb325250c94b9e70e5142fb029f7ee9314194ef4a086fbbfc190945d19139086629bd55c0c00aca8b04680a82389e573fcb0d0055e62c171
+DIST avogadro2-2.0.0-i18n.tar.gz 1572705 BLAKE2B ab9bdbc6e8095f9866754decf254db75d9018ea9217a42967562162fc409695b91896708ebd51bb4969ccce2e92d58c4732d4642b0c5d92695a347970b536ee2 SHA512 34793f87f81462d648c4acc4f61ec7a4ce48b626c8699f72a3720e845c235bd8d02ab7670bb68bc6ce728fd469ef0c924eb5b4fa4f54aa2d23dba5e1a4445339
+DIST avogadro2-2.0.0.tar.gz 3878161 BLAKE2B b6679d9ca07ff1d13eaa70170bed4df6c1968104556c60a2aa94c6848b87e4fe1267ff52afd5b39be6e900e4bbe0398f21ec620b08f7ba74b7541071ae762294 SHA512 235f9b1f4f0d5366b219c21c4e8938b4c21e6020f130ebfcaa281cc0c6e131ba42d87108b2ac74ff27d539a16515975a1b5fad3fbef4ea73a1f738372c9e6826
diff --git a/sci-chemistry/avogadro2/avogadro2-2.0.0.ebuild b/sci-chemistry/avogadro2/avogadro2-2.0.0.ebuild
new file mode 100644
index 0000000000000..918490a468213
--- /dev/null
+++ b/sci-chemistry/avogadro2/avogadro2-2.0.0.ebuild
@@ -0,0 +1,91 @@
+# Copyright 1999-2026 Gentoo Authors
+# Distributed under the terms of the GNU General Public License v2
+
+EAPI=8
+
+MY_PN=avogadroapp
+inherit cmake optfeature xdg
+
+DESCRIPTION="Advanced molecule editor and visualizer 2"
+HOMEPAGE="https://www.openchemistry.org/ https://two.avogadro.cc/"
+SRC_URI="
+	https://github.com/OpenChemistry/${MY_PN}/archive/${PV}.tar.gz -> ${P}.tar.gz
+	https://github.com/OpenChemistry/avogadro-i18n/archive/${PV}.tar.gz -> ${P}-i18n.tar.gz
+"
+S="${WORKDIR}/${MY_PN}-${PV}"
+
+LICENSE="BSD GPL-2+"
+SLOT="0"
+KEYWORDS="~amd64 ~x86"
+IUSE="doc rpc"
+
+RDEPEND="
+	dev-qt/qtbase:6[concurrent,gui,network,opengl,ssl,widgets]
+	~sci-libs/avogadrolibs-${PV}[archive,qt6]
+"
+DEPEND="
+	${RDEPEND}
+	dev-cpp/eigen:3
+"
+BDEPEND="doc? ( app-text/doxygen )"
+
+src_unpack() {
+	default
+	mv "${WORKDIR}"/avogadro-i18n-${PV} "${WORKDIR}"/avogadro-i18n || die
+}
+
+src_prepare() {
+	if use doc; then
+		doxygen -u docs/doxyfile.in 2>/dev/null || die
+	fi
+
+	# disable automatic update dialog
+	sed -e '\@  checkUpdate()@s:^:  //:' \
+		-i avogadro/mainwindow.cpp || die
+
+	cmake_src_prepare
+}
+
+src_configure() {
+	local mycmakeargs=(
+		-DCMAKE_SKIP_RPATH=ON
+		-DBUILD_DOCUMENTATION=$(usex doc)
+		-DAvogadro_ENABLE_RPC=$(usex rpc)
+		# test requires qttesting/paraview
+		-DENABLE_TESTING=OFF
+		-DQT_VERSION=6
+		# skip detection of jkqtplotter
+		# avogadrolibs handles it without the need for rebuilding avogadro2
+		-DUSE_PLOTTER=OFF
+	)
+
+	# Need this to prevent overwriting the documentation OUTDIR
+	use doc && mycmakeargs+=(
+			-DChemData_SOURCE_DIR="${S}"
+			-DChemData_BINARY_DIR="${BUILD_DIR}"
+	)
+
+	cmake_src_configure
+}
+
+src_compile() {
+	cmake_src_compile
+
+	use doc && cmake_build documentation
+}
+
+src_install() {
+	use doc && local HTML_DOCS=( "${BUILD_DIR}"/docs/html/. )
+
+	cmake_src_install
+
+	# remove CONTRIBUTING, LICENSE and duplicate README
+	rm -r "${ED}"/usr/share/doc/${PF}/avogadro2 || die
+}
+
+pkg_postinst() {
+	optfeature "environments of downloaded plugins" dev-util/pixi
+	optfeature "charts and spectra" sci-libs/avogadrolibs[jkqtplotter]
+
+	xdg_pkg_postinst
+}