diff --git a/eclass/toolchain-glibc.eclass b/eclass/toolchain-glibc.eclass
index e9cf01cf8c279..6580be2fb1e04 100644
--- a/eclass/toolchain-glibc.eclass
+++ b/eclass/toolchain-glibc.eclass
@@ -796,6 +796,11 @@ glibc_do_configure() {
 
 	if version_is_at_least 2.25 ; then
 		case ${CTARGET} in
+			mips*)
+				# dlopen() detects stack smash on mips n32 ABI.
+				# Cause is unknown: https://bugs.gentoo.org/640130
+				myconf+=( --enable-stack-protector=no )
+				;;
 			powerpc-*)
 				# Currently gcc on powerpc32 generates invalid code for
 				# __builtin_return_address(0) calls. Normally programs
diff --git a/sys-libs/glibc/glibc-2.26-r3.ebuild b/sys-libs/glibc/glibc-2.26-r3.ebuild
index c2f0607994038..0edb97902c852 100644
--- a/sys-libs/glibc/glibc-2.26-r3.ebuild
+++ b/sys-libs/glibc/glibc-2.26-r3.ebuild
@@ -316,6 +316,11 @@ glibc_do_configure() {
 	popd > /dev/null
 
 	case ${CTARGET} in
+		mips*)
+			# dlopen() detects stack smash on mips n32 ABI.
+			# Cause is unknown: https://bugs.gentoo.org/640130
+			myconf+=( --enable-stack-protector=no )
+			;;
 		powerpc-*)
 			# Currently gcc on powerpc32 generates invalid code for
 			# __builtin_return_address(0) calls. Normally programs
diff --git a/sys-libs/glibc/glibc-9999.ebuild b/sys-libs/glibc/glibc-9999.ebuild
index 60b17cfe67bcd..e29a0778fd5dc 100644
--- a/sys-libs/glibc/glibc-9999.ebuild
+++ b/sys-libs/glibc/glibc-9999.ebuild
@@ -316,6 +316,11 @@ glibc_do_configure() {
 	local myconf=()
 
 	case ${CTARGET} in
+		mips*)
+			# dlopen() detects stack smash on mips n32 ABI.
+			# Cause is unknown: https://bugs.gentoo.org/640130
+			myconf+=( --enable-stack-protector=no )
+			;;
 		powerpc-*)
 			# Currently gcc on powerpc32 generates invalid code for
 			# __builtin_return_address(0) calls. Normally programs