diff --git a/mail-filter/afew/Manifest b/mail-filter/afew/Manifest
deleted file mode 100644
index 666bd28556dc6..0000000000000
--- a/mail-filter/afew/Manifest
+++ /dev/null
@@ -1 +0,0 @@
-DIST afew-3.0.1.tar.gz 40092 BLAKE2B 9ce125ec2359f7cf4630b9602b3068327adc06a699d325c90bc9b545df9ce7f3a62623cc733dfec55ee3e51523e4512ebec04e7186470fc56bb1589a7141cbc9 SHA512 1a76ecc78ed9fb8598be74c48a1d51c78db20df08b27c04c24779aaba01aa457c776457a647c54a5e92f0fda364a86810957a95c0d3f686e77e083d2103b1bf1
diff --git a/mail-filter/afew/afew-3.0.1-r1.ebuild b/mail-filter/afew/afew-3.0.1-r1.ebuild
deleted file mode 100644
index ad2c78a19c9ee..0000000000000
--- a/mail-filter/afew/afew-3.0.1-r1.ebuild
+++ /dev/null
@@ -1,61 +0,0 @@
-# Copyright 1999-2024 Gentoo Authors
-# Distributed under the terms of the GNU General Public License v2
-
-EAPI=8
-
-DISTUTILS_SINGLE_IMPL=1
-DISTUTILS_USE_SETUPTOOLS=rdepend
-PYTHON_COMPAT=( python3_{10..12} )
-
-inherit distutils-r1 pypi
-
-DESCRIPTION="Initial tagging script for Notmuch"
-HOMEPAGE="https://github.com/afewmail/afew"
-
-LICENSE="ISC"
-SLOT="0"
-KEYWORDS="amd64 x86"
-IUSE="doc"
-
-RDEPEND="
- $(python_gen_cond_dep '
- dev-python/chardet[${PYTHON_USEDEP}]
- dev-python/dkimpy[${PYTHON_USEDEP}]
- net-mail/notmuch[python,${PYTHON_USEDEP}]
- ')"
-BDEPEND="
- $(python_gen_cond_dep '
- dev-python/sphinx[${PYTHON_USEDEP}]
- ')
- test? (
- $(python_gen_cond_dep '
- dev-python/freezegun[${PYTHON_USEDEP}]
- ')
- )"
-
-DOCS=( "README.rst" )
-
-distutils_enable_tests pytest
-
-python_prepare_all() {
- sed -r \
- -e "s/^([[:space:]]+)use_scm_version=.*,$/\1version='${PV}',/" \
- -e "/^([[:space:]]+)setup_requires=.*,$/d" \
- -i setup.py || die
- distutils-r1_python_prepare_all
-}
-
-python_compile_all() {
- sphinx-build -b man docs docs/build/man || die
-
- if use doc ; then
- sphinx-build -b html docs docs/build/html || die
- fi
-}
-
-python_install_all() {
- doman docs/build/man/*
- dodoc afew/defaults/afew.config
- use doc && HTML_DOCS=( docs/build/html/. )
- einstalldocs
-}
diff --git a/mail-filter/afew/metadata.xml b/mail-filter/afew/metadata.xml
deleted file mode 100644
index b62f0f7ba5516..0000000000000
--- a/mail-filter/afew/metadata.xml
+++ /dev/null
@@ -1,29 +0,0 @@
-
-
-
-
- guillaumeseren@gmail.com
- Guillaume Seren
-
-
- proxy-maint@gentoo.org
- Proxy Maintainers
-
-
- afew is an initial tagging script for Notmuch. Its basic task is to
- provide automatic tagging each time new mail is registered with Notmuch.
-
- In addition to more elementary features such as adding tags based on
- e-mail headers or maildir folders, handling killed threads and spam, it
- can do some heavy magic in order to learn how to initially tag your
- mails based on their content.
-
- In move mode, afew will move mails between maildir folders according to
- configurable rules that can contain arbitrary notmuch queries to match
- against any searchable attributes.
-
-
- afewmail/afew
- afew
-
-
diff --git a/profiles/package.mask b/profiles/package.mask
index 4125244ca493b..fb472eddc1ae6 100644
--- a/profiles/package.mask
+++ b/profiles/package.mask
@@ -232,13 +232,6 @@ dev-python/pip-run
# Removal on 2025-04-21. Bugs #951854, #909910, #929427.
dev-libs/pigpio
-# Michał Górny (2025-03-22)
-# Depends on deprecated notmuch bindings. The migration to new bindings
-# have not been finished in 5 years already. Still uses legacy
-# distutils-r1.eclass mode.
-# Removal on 2025-04-21. Bug #751541.
-mail-filter/afew
-
# Michał Górny (2025-03-17)
# Xfce 4.22 prereleases. Masked because they tend to be quite unstable.
>=xfce-base/exo-4.21