diff --git a/sci-chemistry/gromacs/gromacs-2021.2.ebuild b/sci-chemistry/gromacs/gromacs-2021.2.ebuild
index 16a2bffe6a33e..e8cbb127fefdd 100644
--- a/sci-chemistry/gromacs/gromacs-2021.2.ebuild
+++ b/sci-chemistry/gromacs/gromacs-2021.2.ebuild
@@ -44,7 +44,7 @@ CDEPEND="
 		x11-libs/libICE
 		)
 	blas? ( virtual/blas )
-	cuda? ( >=dev-util/nvidia-cuda-toolkit-6.5.14 )
+	cuda? ( >=dev-util/nvidia-cuda-toolkit-6.5.14[profiler] )
 	opencl? ( virtual/opencl )
 	fftw? ( sci-libs/fftw:3.0 )
 	hwloc? ( sys-apps/hwloc )
diff --git a/sci-chemistry/gromacs/gromacs-2021.9999.ebuild b/sci-chemistry/gromacs/gromacs-2021.9999.ebuild
index 2323f9d1d8b66..19c3097b599b6 100644
--- a/sci-chemistry/gromacs/gromacs-2021.9999.ebuild
+++ b/sci-chemistry/gromacs/gromacs-2021.9999.ebuild
@@ -44,7 +44,7 @@ CDEPEND="
 		x11-libs/libICE
 		)
 	blas? ( virtual/blas )
-	cuda? ( >=dev-util/nvidia-cuda-toolkit-6.5.14 )
+	cuda? ( >=dev-util/nvidia-cuda-toolkit-6.5.14[profiler] )
 	opencl? ( virtual/opencl )
 	fftw? ( sci-libs/fftw:3.0 )
 	hwloc? ( sys-apps/hwloc )
diff --git a/sci-chemistry/gromacs/gromacs-9999.ebuild b/sci-chemistry/gromacs/gromacs-9999.ebuild
index 2323f9d1d8b66..19c3097b599b6 100644
--- a/sci-chemistry/gromacs/gromacs-9999.ebuild
+++ b/sci-chemistry/gromacs/gromacs-9999.ebuild
@@ -44,7 +44,7 @@ CDEPEND="
 		x11-libs/libICE
 		)
 	blas? ( virtual/blas )
-	cuda? ( >=dev-util/nvidia-cuda-toolkit-6.5.14 )
+	cuda? ( >=dev-util/nvidia-cuda-toolkit-6.5.14[profiler] )
 	opencl? ( virtual/opencl )
 	fftw? ( sci-libs/fftw:3.0 )
 	hwloc? ( sys-apps/hwloc )