diff --git a/dev-python/pygobject/Manifest b/dev-python/pygobject/Manifest
index d865e5cf53a6..0c1eda9e9114 100644
--- a/dev-python/pygobject/Manifest
+++ b/dev-python/pygobject/Manifest
@@ -1,5 +1,6 @@
 DIST pygobject-3.48.2.tar.xz 556244 BLAKE2B 6ac7a42752d65668f228aa9823a4e256b030bc84683857e5470bc373eaaf383904d18399379b4a7d0989644e2b0825d63cc8b3f927b97608a209f888bf8cb276 SHA512 11619f73be5894fae82b261779f33390d1aec51b02bcf285c58f3c76ee46dfc1b3f435e4662176fde5ca899aee5afc453f8f0ba28e15e15330a52354cf737d45
 DIST pygobject-3.50.0.tar.xz 929848 BLAKE2B 1f3d27f055132e82c7aff2f4aa664d1dec57096027a4ceaf9c7245d0e05627d4ba5a8cb7396d35cec4ccf86db9cfedcf9f18a200252fffd00340888e95909c09 SHA512 59edec92b29f3101e4f1afd83a37f4d490e8d833e0dbba9ae8c30891541767e3738bb748ed939b2baef1041eec88f192188d38a82712f1ebc089005b4d6f03a9
+DIST pygobject-3.50.1.tar.gz 1081846 BLAKE2B 7c6fd07e913f64d925838efc6fa0603fef2298779bee15c2c2b2325dd39942ac4856e71846077b6c89e2b05508d66ce606430433257bbb9d6388a4613436615f SHA512 5708756cbc8e2b697442953a7f3d391ace98f1b7811cb905b0d80185f020bf32a775d70c49d1620a9733e83a6862314f2a72fa1b77cb26a01e84b3bff72e068e
 DIST pygobject-3.52.3.tar.gz 1235825 BLAKE2B f9d95ff9e12b6d6fb5c36d1528ff4ef45e6799316ac21b0f79364dc438bf4e0e6670489f23e0ca4325fc21d16cc2d96fe6aff61f71b8bfe768df2c487717e6df SHA512 06085df458076120017ace7a029ac6c00757ae1882a2a50041aadd7f4c2a329a0fb4d18dde02a481c1f4d3acecbc9d8f473f4ae23fbbfc4f885f75bbc7847f24
 DIST pygobject-3.52.3_0a8b2c56331a31d7f7096faaa1c1c26467b51c15_pythoncapi-compat.gh.tar.gz 50124 BLAKE2B 67bb1e60d10d72b146ae2f8ca0113939916fa67a3c71c3658343ff3742315768471e50c0254a3f9488031297d6697dbb0e8541bfe72e8b0754ede09fb9d65da8 SHA512 3fff69f471e28b47bbb537d31d182180631090c00aaf45931aad128f4cb700cdfd519ce560610b7e57132ad7d172b8f2bc4cd16cf748f218dafdadd15fc48718
-DIST pygobject-3.50.1.tar.gz 1081846 BLAKE2B 7c6fd07e913f64d925838efc6fa0603fef2298779bee15c2c2b2325dd39942ac4856e71846077b6c89e2b05508d66ce606430433257bbb9d6388a4613436615f SHA512 5708756cbc8e2b697442953a7f3d391ace98f1b7811cb905b0d80185f020bf32a775d70c49d1620a9733e83a6862314f2a72fa1b77cb26a01e84b3bff72e068e
+DIST pygobject-3.54.3.tar.gz 1272609 BLAKE2B d80dded1d2ac7dbc20dddfe5c05a4f03eb9619a32475725211562a883f6637d90b9be213fa5b49fd214663422584340297c6b8c6655042cb011058dd6d3ec729 SHA512 d3052c99133703560ca70d53461bf6fbdb1397cec179a9ea47fd59fcce595611f33040b974bea95e11affb733be27f2693252d002ec68f08a7ecae3382dac898
diff --git a/dev-python/pygobject/pygobject-3.54.3.ebuild b/dev-python/pygobject/pygobject-3.54.3.ebuild
new file mode 100644
index 000000000000..2bfb01fca00f
--- /dev/null
+++ b/dev-python/pygobject/pygobject-3.54.3.ebuild
@@ -0,0 +1,82 @@
+# Copyright 1999-2025 Gentoo Authors
+# Distributed under the terms of the GNU General Public License v2
+
+EAPI=8
+
+DISTUTILS_EXT=1
+DISTUTILS_USE_PEP517=no
+GNOME_TARBALL_SUFFIX="gz"
+PYTHON_COMPAT=( python3_{11..14} pypy3_11 )
+
+inherit gnome.org meson virtualx xdg distutils-r1
+
+DESCRIPTION="Python bindings for GObject Introspection"
+HOMEPAGE="
+	https://pygobject.gnome.org/
+	https://gitlab.gnome.org/GNOME/pygobject/
+"
+
+LICENSE="LGPL-2.1+"
+SLOT="3"
+KEYWORDS="~alpha ~amd64 ~arm ~arm64 ~hppa ~loong ~mips ~ppc ~ppc64 ~riscv ~s390 ~sparc ~x86 ~amd64-linux ~x86-linux ~ppc-macos ~x64-macos ~x64-solaris"
+IUSE="+cairo test"
+RESTRICT="!test? ( test )"
+
+RDEPEND="
+	>=dev-libs/glib-2.80:2
+	>=dev-libs/gobject-introspection-1.84:=
+	dev-libs/libffi:=
+	cairo? (
+		>=dev-python/pycairo-1.16.0[${PYTHON_USEDEP}]
+		x11-libs/cairo[glib]
+	)
+"
+DEPEND="
+	${RDEPEND}
+	test? (
+		>=app-accessibility/at-spi2-core-2.46.0[introspection]
+		dev-python/pytest[${PYTHON_USEDEP}]
+		x11-libs/gdk-pixbuf:2[introspection,jpeg]
+		x11-libs/gtk+:3[introspection]
+		x11-libs/pango[introspection]
+	)
+"
+BDEPEND="
+	virtual/pkgconfig
+"
+
+PATCHES=(
+	"${FILESDIR}/Skip-test-using-dbus-in-sandbox.patch"
+	"${FILESDIR}/Skip-test-detecting-cycle-among-base-classes-typeerr.patch"
+)
+
+python_configure() {
+	local emesonargs=(
+		$(meson_feature cairo pycairo)
+		$(meson_use test tests)
+		-Dpython="${EPYTHON}"
+	)
+	meson_src_configure
+}
+
+python_compile() {
+	meson_src_compile
+}
+
+src_test() {
+	virtx distutils-r1_src_test
+}
+
+python_test() {
+	local -x GIO_USE_VFS="local" # prevents odd issues with deleting ${T}/.gvfs
+	local -x GIO_USE_VOLUME_MONITOR="unix" # prevent udisks-related failures in chroots, bug #449484
+	local -x PYTEST_DISABLE_PLUGIN_AUTOLOAD=1
+	local -x XDG_CACHE_HOME="${T}/${EPYTHON}"
+
+	meson_src_test --timeout-multiplier 3 || die "test for ${EPYTHON}"
+}
+
+python_install() {
+	meson_src_install
+	python_optimize
+}