diff --git a/dev-python/pyro/Manifest b/dev-python/Pyro4/Manifest
similarity index 100%
rename from dev-python/pyro/Manifest
rename to dev-python/Pyro4/Manifest
diff --git a/dev-python/pyro/pyro-4.80.ebuild b/dev-python/Pyro4/Pyro4-4.80.ebuild
similarity index 98%
rename from dev-python/pyro/pyro-4.80.ebuild
rename to dev-python/Pyro4/Pyro4-4.80.ebuild
index 1c2150e74eee4..017c7345206d7 100644
--- a/dev-python/pyro/pyro-4.80.ebuild
+++ b/dev-python/Pyro4/Pyro4-4.80.ebuild
@@ -22,7 +22,6 @@ IUSE="doc examples test"
 RESTRICT="!test? ( test )"
 
 RDEPEND="
-	!dev-python/pyro:0
 	>=dev-python/serpent-1.27[${PYTHON_USEDEP}]"
 DEPEND="${RDEPEND}
 	test? (
diff --git a/dev-python/pyro/metadata.xml b/dev-python/Pyro4/metadata.xml
similarity index 100%
rename from dev-python/pyro/metadata.xml
rename to dev-python/Pyro4/metadata.xml
diff --git a/dev-python/kombu/kombu-5.1.0.ebuild b/dev-python/kombu/kombu-5.1.0.ebuild
index 5d90881cb0c64..22dee35e6bf55 100644
--- a/dev-python/kombu/kombu-5.1.0.ebuild
+++ b/dev-python/kombu/kombu-5.1.0.ebuild
@@ -29,7 +29,7 @@ BDEPEND="
 		>=dev-python/msgpack-0.3.0[${PYTHON_USEDEP}]
 		dev-python/pycurl[${PYTHON_USEDEP}]
 		>=dev-python/pymongo-3.3.0[${PYTHON_USEDEP}]
-		dev-python/pyro:4[${PYTHON_USEDEP}]
+		dev-python/Pyro4[${PYTHON_USEDEP}]
 		dev-python/pytz[${PYTHON_USEDEP}]
 		>=dev-python/pyyaml-3.10[${PYTHON_USEDEP}]
 		>=dev-python/redis-py-3.3.11[${PYTHON_USEDEP}]
@@ -66,7 +66,7 @@ pkg_postinst() {
 	optfeature "Amazon SQS backend" "dev-python/boto3 dev-python/pycurl"
 	optfeature "Etcd backend" dev-python/python-etcd
 	optfeature "MongoDB backend" dev-python/pymongo
-	optfeature "Pyro 4 backend" dev-python/pyro:4
+	optfeature "Pyro 4 backend" dev-python/Pyro4
 	optfeature "Redis backend" dev-python/redis-py
 	optfeature "sqlalchemy backend" dev-python/sqlalchemy
 	optfeature "yaml backend" dev-python/pyyaml
diff --git a/dev-python/pyscard/pyscard-2.0.1.ebuild b/dev-python/pyscard/pyscard-2.0.1.ebuild
index 7aa7611328f03..490132595edaa 100644
--- a/dev-python/pyscard/pyscard-2.0.1.ebuild
+++ b/dev-python/pyscard/pyscard-2.0.1.ebuild
@@ -25,5 +25,5 @@ distutils_enable_tests setup.py
 
 pkg_postinst() {
 	optfeature "Gui support" dev-python/wxpython
-	optfeature "Support of remote readers with Pyro" dev-python/pyro
+	optfeature "Support of remote readers with Pyro" dev-python/Pyro4
 }
diff --git a/profiles/updates/3Q-2021 b/profiles/updates/3Q-2021
index 9dee690416508..ced2871dc4df8 100644
--- a/profiles/updates/3Q-2021
+++ b/profiles/updates/3Q-2021
@@ -11,3 +11,4 @@ move dev-python/u-msgpack dev-python/u-msgpack-python
 move sci-physics/geant-vmc sci-physics/geant4_vmc
 move dev-python/beautifulsoup dev-python/beautifulsoup4
 slotmove dev-python/beautifulsoup4 4 0
+move dev-python/pyro dev-python/Pyro4