diff --git a/dev-python/httpx/Manifest b/dev-python/httpx/Manifest
index eae5368853184..384fbc91716ee 100644
--- a/dev-python/httpx/Manifest
+++ b/dev-python/httpx/Manifest
@@ -1 +1,2 @@
 DIST httpx-0.19.0.tar.gz 1667455 BLAKE2B b8d4cb0b6e7f643b62b507930ccf1534d73d93261cab9281ef57d6392f00da325e897d5339aebacfa07aeae8278d3a81b78d6501a1587ffeaef68cc5087bfdaa SHA512 3b327f07d62cf0430672d4f1a4f884618e588496f049522de327f5c34f7260eb21739b7f1fbd6f43a21962bc8737547f3eddbc22751546647f56c9cd7212840a
+DIST httpx-0.21.1.tar.gz 2155133 BLAKE2B c3c800657abaed461ab6f44e3cd9799be4b6499070a5db2ee8d5d61c776d86591c74192eb1c88d4072dc361ea4c9448a3ed061c715fa4504fc931fdd96ccde62 SHA512 a4f737f6c6ae909fd3ea811e0ff3b78ed6496da8d797ef49746f744216e055f8225d613fe935d5e2780aa1b233053ad436e8849eef578e662ca8ee34513ad12e
diff --git a/dev-python/httpx/httpx-0.21.1.ebuild b/dev-python/httpx/httpx-0.21.1.ebuild
new file mode 100644
index 0000000000000..7a7b38bdf26da
--- /dev/null
+++ b/dev-python/httpx/httpx-0.21.1.ebuild
@@ -0,0 +1,74 @@
+# Copyright 2021 Gentoo Authors
+# Distributed under the terms of the GNU General Public License v2
+
+EAPI=8
+
+# Docs builder mkdocs not keyworded on all these arches yet
+# DOCS_BUILDER="mkdocs"
+# DOCS_DEPEND="dev-python/mkdocs-material"
+# DOCS_AUTODOC=1
+PYTHON_COMPAT=( python3_{8..10} )
+
+inherit distutils-r1 # docs
+
+DESCRIPTION="Fully-featured HTTP client which provides sync and async APIs"
+HOMEPAGE="https://www.python-httpx.org/"
+SRC_URI="https://github.com/encode/${PN}/archive/${PV}.tar.gz -> ${P}.tar.gz"
+
+LICENSE="BSD"
+SLOT="0"
+KEYWORDS="~amd64 ~riscv ~x86"
+IUSE="cli"
+
+RDEPEND="
+	dev-python/certifi[${PYTHON_USEDEP}]
+	dev-python/charset_normalizer[${PYTHON_USEDEP}]
+	dev-python/sniffio[${PYTHON_USEDEP}]
+	=dev-python/httpcore-0.14*[${PYTHON_USEDEP}]
+	>=dev-python/rfc3986-1.3[${PYTHON_USEDEP}]
+	<dev-python/rfc3986-2[${PYTHON_USEDEP}]
+	cli? (
+		=dev-python/click-8*[${PYTHON_USEDEP}]
+		=dev-python/pygments-2*[${PYTHON_USEDEP}]
+		=dev-python/rich-10*[${PYTHON_USEDEP}]
+	)
+"
+BDEPEND="
+	test? (
+		dev-python/brotlicffi[${PYTHON_USEDEP}]
+		dev-python/cryptography[${PYTHON_USEDEP}]
+		dev-python/h2[${PYTHON_USEDEP}]
+		dev-python/pytest-asyncio[${PYTHON_USEDEP}]
+		dev-python/trustme[${PYTHON_USEDEP}]
+		dev-python/typing-extensions[${PYTHON_USEDEP}]
+		dev-python/uvicorn[${PYTHON_USEDEP}]
+	)
+"
+
+distutils_enable_tests pytest
+
+src_prepare() {
+	if ! use cli; then
+		sed -i -e '/console_scripts/d' setup.py || die
+	fi
+	distutils-r1_src_prepare
+}
+
+python_test() {
+	local EPYTEST_DESELECT=(
+		# Internet
+		tests/client/test_proxies.py::test_async_proxy_close
+		tests/client/test_proxies.py::test_sync_proxy_close
+
+		# Result change in charset-normalizer-2.0.7+
+		'tests/test_decoders.py::test_text_decoder[data3-iso-8859-1]'
+		'tests/models/test_responses.py::test_response_no_charset_with_iso_8859_1_content'
+	)
+	local EPYTEST_IGNORE=()
+
+	use cli || EPYTEST_IGNORE+=(
+		tests/test_main.py
+	)
+
+	epytest
+}
diff --git a/dev-python/httpx/metadata.xml b/dev-python/httpx/metadata.xml
index bc0ee8c44b9a2..ed555c30e50ab 100644
--- a/dev-python/httpx/metadata.xml
+++ b/dev-python/httpx/metadata.xml
@@ -11,4 +11,7 @@
 		<remote-id type="github">encode/httpx</remote-id>
 		<bugs-to>https://github.com/encode/httpx/issues</bugs-to>
 	</upstream>
+	<use>
+		<flag name="cli">Install the CLI "httpx" client.</flag>
+	</use>
 </pkgmetadata>