diff --git a/dev-python/typeguard/Manifest b/dev-python/typeguard/Manifest
new file mode 100644
index 0000000000000..cfe8c9dbb7443
--- /dev/null
+++ b/dev-python/typeguard/Manifest
@@ -0,0 +1 @@
+DIST typeguard-2.12.1.gh.tar.gz 35894 BLAKE2B 309b5fd906ae5122fbd2134ff30f6f2908a5d64fc8510dd054a9f47feef5f1674ea6133156fb6649c85a6fc8a98609387f742e7f9588db8ab008ef2caec0c740 SHA512 ea91140ba0ebfe7cc83bf212ae20aca777279fc88ff806bf6a1f4208581bb726c6091d0777371d487e7422887814d81c84ebac9f06bfacc5a929f5a2657312a8
diff --git a/dev-python/typeguard/metadata.xml b/dev-python/typeguard/metadata.xml
new file mode 100644
index 0000000000000..4522c923343ff
--- /dev/null
+++ b/dev-python/typeguard/metadata.xml
@@ -0,0 +1,11 @@
+<?xml version="1.0" encoding="UTF-8"?>
+<!DOCTYPE pkgmetadata SYSTEM "http://www.gentoo.org/dtd/metadata.dtd">
+<pkgmetadata>
+	<maintainer type="project">
+		<email>python@gentoo.org</email>
+	</maintainer>
+	<upstream>
+		<remote-id type="github">agronholm/typeguard</remote-id>
+		<remote-id type="pypi">typeguard</remote-id>
+	</upstream>
+</pkgmetadata>
diff --git a/dev-python/typeguard/typeguard-2.12.1.ebuild b/dev-python/typeguard/typeguard-2.12.1.ebuild
new file mode 100644
index 0000000000000..92dfba2742eaa
--- /dev/null
+++ b/dev-python/typeguard/typeguard-2.12.1.ebuild
@@ -0,0 +1,40 @@
+# Copyright 2021 Gentoo Authors
+# Distributed under the terms of the GNU General Public License v2
+
+EAPI=8
+
+PYTHON_COMPAT=( python3_{8..10} )
+inherit distutils-r1
+
+DESCRIPTION="Run-time type checker for Python"
+HOMEPAGE="
+	https://pypi.org/project/typeguard/
+	https://github.com/agronholm/typeguard/"
+SRC_URI="
+	https://github.com/agronholm/typeguard/archive/${PV}.tar.gz
+		-> ${P}.gh.tar.gz"
+
+LICENSE="MIT"
+SLOT="0"
+KEYWORDS="~amd64 ~x86"
+
+BDEPEND="
+	dev-python/setuptools_scm[${PYTHON_USEDEP}]
+	test? (
+		dev-python/typing-extensions[${PYTHON_USEDEP}]
+	)"
+
+distutils_enable_tests pytest
+
+export SETUPTOOLS_SCM_PRETEND_VERSION=${PV}
+
+python_test() {
+	local -x PYTHONDONTWRITEBYTECODE=
+	local deselect=()
+	[[ ${EPYTHON} == python3.10 ]] && deselect+=(
+		# https://github.com/agronholm/typeguard/issues/199
+		tests/test_typeguard.py::TestCheckArgumentTypes::test_newtype
+	)
+	# mypy changes results from version to version
+	epytest --ignore tests/mypy ${deselect[@]/#/--deselect }
+}