diff --git a/dev-python/PyUtilib/PyUtilib-6.0.0.ebuild b/dev-python/PyUtilib/PyUtilib-6.0.0.ebuild
index d0f3e6c388551..fe1c027f23dac 100644
--- a/dev-python/PyUtilib/PyUtilib-6.0.0.ebuild
+++ b/dev-python/PyUtilib/PyUtilib-6.0.0.ebuild
@@ -3,8 +3,7 @@
 
 EAPI=7
 
-DISTUTILS_USE_SETUPTOOLS=rdepend
-PYTHON_COMPAT=( python3_{7..9} )
+PYTHON_COMPAT=( python3_{8..10} )
 DISTUTILS_IN_SOURCE_BUILD=1
 
 inherit distutils-r1
@@ -18,6 +17,9 @@ LICENSE="BSD"
 SLOT="0"
 KEYWORDS="~amd64 ~x86"
 
+RDEPEND="dev-python/six[${PYTHON_USEDEP}]"
+BDEPEND="test? ( dev-python/nose[${PYTHON_USEDEP}] )"
+
 PATCHES=(
 	"${FILESDIR}/PyUtilib-6.0.0-tests.patch"
 )
@@ -36,5 +38,12 @@ python_test() {
 	local -x PYTHONPATH="${PWD}:${TEST_DIR}/lib" \
 		COLUMNS=80
 
+	if [[ ${EPYTHON} == python3.10 ]]; then
+		# Fix for very small output change of expected output in new version
+		sed -e 's/optional arguments/options/' -i \
+			"${BUILD_DIR}/../doc/workflow/examples/"*.txt \
+			pyutilib/misc/tests/test_config.py || die
+	fi
+
 	eunittest
 }