diff --git a/profiles/arch/arm/use.stable.mask b/profiles/arch/arm/use.stable.mask
index 9329affc5dc88..f4e2ecac1ba4d 100644
--- a/profiles/arch/arm/use.stable.mask
+++ b/profiles/arch/arm/use.stable.mask
@@ -30,7 +30,6 @@ gimp
 # Mattéo Rossillol‑‑Laruelle <beatussum@protonmail.com> (2019‑08‑31)
 # Dependencies not yet stable.
 appindicator
-ayatana
 
 # Andrey Grozin <grozin@gentoo.org> (2014-05-16)
 # No stable gcl
diff --git a/profiles/arch/arm64/use.mask b/profiles/arch/arm64/use.mask
index f652ff6f5267a..d32c7c4ee25c7 100644
--- a/profiles/arch/arm64/use.mask
+++ b/profiles/arch/arm64/use.mask
@@ -53,7 +53,6 @@ cpu_flags_arm_neon
 # Mattéo Rossillol‑‑Laruelle <beatussum@protonmail.com> (2019‑08‑31)
 # Dependency not keyworded (dev-libs/libindicate).
 appindicator
-ayatana
 
 # Michał Górny <mgorny@gentoo.org> (2018-07-09)
 # No OpenCL provider is available on arm64.
diff --git a/profiles/arch/hppa/use.mask b/profiles/arch/hppa/use.mask
index 98774ff4b52d0..e561ee2f467c2 100644
--- a/profiles/arch/hppa/use.mask
+++ b/profiles/arch/hppa/use.mask
@@ -40,7 +40,6 @@ vpx
 # Mattéo Rossillol‑‑Laruelle <beatussum@protonmail.com> (2019‑08‑31)
 # Dependency not keyworded (dev-libs/libappindicator).
 appindicator
-ayatana
 
 # Matt Turner <mattst88@gentoo.org> (2018-05-26)
 # Unmask systemd since it is keyworded here.
diff --git a/profiles/arch/ia64/use.mask b/profiles/arch/ia64/use.mask
index 3bb8098c052e8..a3f9822da813c 100644
--- a/profiles/arch/ia64/use.mask
+++ b/profiles/arch/ia64/use.mask
@@ -41,7 +41,6 @@ gnome-online-accounts
 # Mattéo Rossillol‑‑Laruelle <beatussum@protonmail.com> (2019‑08‑31)
 # Dependency not keyworded (dev-libs/libindicate).
 appindicator
-ayatana
 
 # Sergei Trofimovich <slyfox@gentoo.org> (2017-06-17)
 # There is no luajit support on ia64. Bug #554376
diff --git a/profiles/arch/m68k/use.mask b/profiles/arch/m68k/use.mask
index ba76d25819bb2..297d48be89a78 100644
--- a/profiles/arch/m68k/use.mask
+++ b/profiles/arch/m68k/use.mask
@@ -96,7 +96,6 @@ valgrind
 # Mattéo Rossillol‑‑Laruelle <beatussum@protonmail.com> (2019‑08‑31)
 # Dependencies not keyworded.
 appindicator
-ayatana
 
 # Andreas Sturmlechner <asturm@gentoo.org> (2019-03-31)
 # sys-auth/elogind is not keyworded here.
diff --git a/profiles/arch/mips/use.mask b/profiles/arch/mips/use.mask
index 2e6d18e809f53..85e68d05e19cd 100644
--- a/profiles/arch/mips/use.mask
+++ b/profiles/arch/mips/use.mask
@@ -48,7 +48,6 @@ samba
 # Mart Raudsepp <leio@gentoo.org> (2017-02-07)
 # dev-libs/libappindicator not tested
 appindicator
-ayatana
 
 # Anthony G. Basile <blueness@gentoo.org> (2015-08-01)
 # There is no luajit support on mips.  Bug #554376.
diff --git a/profiles/arch/powerpc/use.mask b/profiles/arch/powerpc/use.mask
index 05881727de155..5a92cd7a0e0fd 100644
--- a/profiles/arch/powerpc/use.mask
+++ b/profiles/arch/powerpc/use.mask
@@ -1,4 +1,4 @@
-# Copyright 1999-2021 Gentoo Authors
+# Copyright 1999-2022 Gentoo Authors
 # Distributed under the terms of the GNU General Public License v2
 
 # PPC Specific use flags
@@ -52,7 +52,6 @@ gnuefi
 # Patrick Lauer <patrick@gentoo.org> (2015-04-28)
 # dependencies not keyworded yet
 appindicator
-ayatana
 
 # These flags should only be used for ppc
 -ppcsha1
diff --git a/profiles/arch/s390/use.mask b/profiles/arch/s390/use.mask
index 1dee45c7eabe1..c4f3c6a8e82b1 100644
--- a/profiles/arch/s390/use.mask
+++ b/profiles/arch/s390/use.mask
@@ -61,7 +61,6 @@ libglvnd
 # Mattéo Rossillol‑‑Laruelle <beatussum@protonmail.com> (2019‑08‑31)
 # Dependencies not keyworded.
 appindicator
-ayatana
 
 # James Le Cuirot <chewi@gentoo.org> (2017-06-29)
 # Unmask as this profile is big endian.
diff --git a/profiles/arch/sparc/use.mask b/profiles/arch/sparc/use.mask
index a88935985b69a..30eeb4fb2ca30 100644
--- a/profiles/arch/sparc/use.mask
+++ b/profiles/arch/sparc/use.mask
@@ -43,7 +43,6 @@ gimp
 # Mattéo Rossillol‑‑Laruelle <beatussum@protonmail.com> (2019‑08‑31)
 # Dependency not keyworded (dev-libs/libappindicator).
 appindicator
-ayatana
 
 # Sergei Trofimovich <slyfox@gentoo.org> (2018-12-12)
 # mongodb is not keyworded on sparc
diff --git a/profiles/use.desc b/profiles/use.desc
index a3b6b0d0f3392..52f51fa3cdbec 100644
--- a/profiles/use.desc
+++ b/profiles/use.desc
@@ -22,7 +22,6 @@ atm - Enable Asynchronous Transfer Mode protocol support
 appindicator - Build in support for notifications using the libindicate or libappindicator plugin
 audiofile - Add support for libaudiofile where applicable
 audit - Enable support for Linux audit subsystem using sys-process/audit
-ayatana - Build in support for Ayatana notification using the libindicate or libappindicator plugin
 bash-completion - Enable bash-completion support
 berkdb - Add support for sys-libs/db (Berkeley DB for MySQL)
 bidi - Enable bidirectional language support