diff --git a/dev-python/cloudpickle/cloudpickle-3.0.0.ebuild b/dev-python/cloudpickle/cloudpickle-3.0.0.ebuild
index ef1658bb7c890..f840b44245798 100644
--- a/dev-python/cloudpickle/cloudpickle-3.0.0.ebuild
+++ b/dev-python/cloudpickle/cloudpickle-3.0.0.ebuild
@@ -1,4 +1,4 @@
-# Copyright 1999-2023 Gentoo Authors
+# Copyright 1999-2024 Gentoo Authors
 # Distributed under the terms of the GNU General Public License v2
 
 EAPI=8
@@ -31,6 +31,7 @@ BDEPEND="
 distutils_enable_tests pytest
 
 python_test() {
+	local -x PYTEST_DISABLE_PLUGIN_AUTOLOAD=1
 	local -x PYTHONPATH=${PYTHONPATH}:tests/cloudpickle_testpkg
 	# -s unbreaks some tests
 	# https://github.com/cloudpipe/cloudpickle/issues/252