diff --git a/dev-python/libtmux/Manifest b/dev-python/libtmux/Manifest
index 465b9e600b076..51e36db00bdc3 100644
--- a/dev-python/libtmux/Manifest
+++ b/dev-python/libtmux/Manifest
@@ -5,3 +5,4 @@ DIST libtmux-0.42.0.gh.tar.gz 318655 BLAKE2B 5d462bd78e81bd38cfb0c42a2100287fc79
 DIST libtmux-0.44.2.gh.tar.gz 326828 BLAKE2B ac2441ac13157bdce2465b1388f3e1570eb48193f26a37cfe6d68e56e93f659410af2851be20cd2f94011298c2b93a54eee20f5d07b4fbff15d26e00bbae6c0c SHA512 383784bb335c0f6e8200e20e8afd5b643658ee081a2c07cb9df2ee682d4b411b3ea17c7607587b8855f7d6571f5db7dd75318eefdd8946e6e38560309b5fa35f
 DIST libtmux-0.45.0.gh.tar.gz 329763 BLAKE2B 3c8184b9e7ab874b4a85e3d3c3be3e96e48bfb14a02bf26a683062374c0a5258d911026a8c994639514668c775ab3855201d1daa466a20041635aeb978cffe24 SHA512 e1f921bddabcc26f034c331d3b9e7082c3d6d4cdbd8f0173e1499d8a05fd80ca79317409b29cb9ac95827ccb6e9127c58dffa6198ea5a2dee547fdaef23ba2ee
 DIST libtmux-0.46.0.gh.tar.gz 337117 BLAKE2B 23caa10584c943ee1e7c162ce97d9d18d297a52fa15a4ac66be2e29314499d2f99bfa5a3061cef6ad80dc94ba8bf9362725d92e74385973aa717849a78388ac4 SHA512 4143639f0219c5751e69718d79c08efec8f9a6f5229aa48f6a7f7fe6c32486ee4b92f6d962fa6ef8f396852a688e373daf0d416f29b95036d015b3fcbba063a9
+DIST libtmux-0.46.1.gh.tar.gz 337302 BLAKE2B b0e086aab882c9ec82ee5606a7ea02e81a549d3009bf8b0f4bc736d8ba8cc7130afd024781c95e332527bdb72202346558d90a4989c5ff2cbb7f6836960e88ef SHA512 41b526d40373d1251260cea8e4fc94cb176275f2c399030b66266663e831f733fb017bebc32e92b9809212c064b21e539853ec780b8f75f0afe01db8b5cb2236
diff --git a/dev-python/libtmux/libtmux-0.46.1.ebuild b/dev-python/libtmux/libtmux-0.46.1.ebuild
new file mode 100644
index 0000000000000..f07f9333b0d03
--- /dev/null
+++ b/dev-python/libtmux/libtmux-0.46.1.ebuild
@@ -0,0 +1,53 @@
+# Copyright 1999-2025 Gentoo Authors
+# Distributed under the terms of the GNU General Public License v2
+
+EAPI=8
+
+DISTUTILS_USE_PEP517=hatchling
+PYTHON_COMPAT=( python3_{10..13} pypy3 pypy3_11 )
+
+inherit distutils-r1
+
+DESCRIPTION="Typed library that provides an ORM wrapper for tmux, a terminal multiplexer"
+HOMEPAGE="
+	https://libtmux.git-pull.com/
+	https://github.com/tmux-python/libtmux/
+	https://pypi.org/project/libtmux/
+"
+SRC_URI="
+	https://github.com/tmux-python/libtmux/archive/v${PV}.tar.gz
+		-> ${P}.gh.tar.gz
+"
+
+LICENSE="MIT"
+SLOT="0"
+KEYWORDS="~amd64 ~arm ~arm64 ~ppc64 ~x86"
+
+RDEPEND="
+	>=app-misc/tmux-3.0a
+"
+BDEPEND="
+	test? (
+		dev-python/pytest-mock[${PYTHON_USEDEP}]
+		dev-python/pytest-rerunfailures[${PYTHON_USEDEP}]
+	)
+"
+
+distutils_enable_tests pytest
+
+python_prepare_all() {
+	local issues="https://github.com/tmux-python/libtmux/issues/"
+	sed -r -i "s|:issue:\`([[:digit:]]+)\`|\`issue \1 ${issues}\1\`|" CHANGES || die
+
+	distutils-r1_python_prepare_all
+}
+
+python_test() {
+	# tests/test_window.py::test_fresh_window_data fails if TMUX_PANE is set
+	# https://bugs.gentoo.org/927158
+	local -x TMUX_PANE=
+	local -x PYTEST_DISABLE_PLUGIN_AUTOLOAD=1
+	local -x PYTEST_PLUGINS=libtmux.pytest_plugin
+
+	epytest -o addopts= -p pytest_mock -p rerunfailures --reruns=5 tests
+}