diff --git a/app-emulation/dosemu/dosemu-1.4.1_pre20130107-r5.ebuild b/app-emulation/dosemu/dosemu-1.4.1_pre20130107-r5.ebuild
index c7771af9cd8f5..61a15bd1f53cd 100644
--- a/app-emulation/dosemu/dosemu-1.4.1_pre20130107-r5.ebuild
+++ b/app-emulation/dosemu/dosemu-1.4.1_pre20130107-r5.ebuild
@@ -58,6 +58,12 @@ PATCHES=(
 	"${FILESDIR}"/${P}-as.patch
 )
 
+pkg_pretend() {
+	if tc-is-clang; then
+		die "${P} does not work on clang due to missing 16-bit assembly support: https://bugs.gentoo.org/729240. Please try gcc."
+	fi
+}
+
 src_prepare() {
 	default