diff --git a/sci-ml/torchvision/Manifest b/sci-ml/torchvision/Manifest
index acbb36f56d7ed..aa765ef093cfb 100644
--- a/sci-ml/torchvision/Manifest
+++ b/sci-ml/torchvision/Manifest
@@ -1 +1,2 @@
 DIST torchvision-0.20.0.tar.gz 13149734 BLAKE2B 49493f2b088305f2d4a7502201c233304dc149dc96f4da2a3e93341e2d4e094fc6cdbc7c0d60cf25b97e698120065378408b557b2b0237d6afda7d1ed534487d SHA512 1db98fcc0ef4c018cd00a2c540bc60a47dd3b161f5128337e4a2f0bcce792273b9902108dc01e7d091a3331d9e35f8ab53503cbdba3f2a3cb3865471e7f63baf
+DIST torchvision-0.21.0.tar.gz 13149842 BLAKE2B 0651356e97ea591ddeaa18edcfb88b566c1e8e6cc19ab68197772ccea4f10b97ed02f84341ca06d152a65018a43ed7993eddcb8a7ca64b168eb91e9ad2711687 SHA512 38f455b05cd0374d7b5cddbc78b5653edca93909943fa3f3d9875be4009cab8f207662c11b46d7a2f27abefd629adc5f4b877ffd87479c4f9f5de93bddd2661f
diff --git a/sci-ml/torchvision/files/torchvision-0.21.0-gentoo.patch b/sci-ml/torchvision/files/torchvision-0.21.0-gentoo.patch
new file mode 100644
index 0000000000000..287eaf3e61771
--- /dev/null
+++ b/sci-ml/torchvision/files/torchvision-0.21.0-gentoo.patch
@@ -0,0 +1,19 @@
+--- a/setup.py	2025-02-22 16:44:42.102439182 +0100
++++ b/setup.py	2025-02-22 16:46:52.393841294 +0100
+@@ -6,6 +6,7 @@
+ import subprocess
+ import sys
+ import warnings
++import shlex
+ from pathlib import Path
+ 
+ import torch
+@@ -127,7 +128,7 @@
+             if NVCC_FLAGS is None:
+                 nvcc_flags = []
+             else:
+-                nvcc_flags = NVCC_FLAGS.split(" ")
++                nvcc_flags = shlex.split(NVCC_FLAGS)
+         extra_compile_args["nvcc"] = nvcc_flags
+ 
+     if sys.platform == "win32":
diff --git a/sci-ml/torchvision/torchvision-0.21.0.ebuild b/sci-ml/torchvision/torchvision-0.21.0.ebuild
new file mode 100644
index 0000000000000..b2c5e6151d4c7
--- /dev/null
+++ b/sci-ml/torchvision/torchvision-0.21.0.ebuild
@@ -0,0 +1,82 @@
+# Copyright 2024-2025 Gentoo Authors
+# Distributed under the terms of the GNU General Public License v2
+
+EAPI=8
+
+PYTHON_COMPAT=( python3_{10..13} )
+DISTUTILS_SINGLE_IMPL=1
+DISTUTILS_USE_PEP517=setuptools
+DISTUTILS_EXT=1
+inherit cuda distutils-r1 multiprocessing
+
+DESCRIPTION="Datasets, transforms and models to specific to computer vision"
+HOMEPAGE="https://github.com/pytorch/vision"
+SRC_URI="https://github.com/pytorch/vision/archive/refs/tags/v${PV}.tar.gz
+	-> ${P}.tar.gz"
+
+S="${WORKDIR}"/vision-${PV}
+
+LICENSE="BSD"
+SLOT="0"
+KEYWORDS="~amd64"
+IUSE="cuda"
+
+RDEPEND="
+	sci-ml/caffe2[cuda?]
+	sci-ml/pytorch[${PYTHON_SINGLE_USEDEP}]
+	dev-python/numpy
+	dev-python/pillow
+	media-libs/libjpeg-turbo:=
+	media-libs/libpng:=
+"
+BDEPEND="
+	test? (
+		$(python_gen_cond_dep '
+			dev-python/pytest-mock[${PYTHON_USEDEP}]
+			dev-python/lmdb[${PYTHON_USEDEP}]
+		')
+	)
+"
+
+PATCHES=( "${FILESDIR}"/${P}-gentoo.patch )
+
+src_prepare() {
+	use cuda && cuda_src_prepare
+	distutils-r1_src_prepare
+}
+
+distutils_enable_tests pytest
+
+python_compile() {
+	addpredict /dev/kfd
+
+	FORCE_CUDA=$(usex cuda 1 0) \
+		NVCC_FLAGS="${NVCCFLAGS}" \
+		MAX_JOBS="$(makeopts_jobs)" \
+		distutils-r1_python_compile -j1
+}
+
+python_test() {
+	rm -rf torchvision || die
+
+	local EPYTEST_IGNORE=(
+		test/test_videoapi.py
+	)
+	local EPYTEST_DESELECT=(
+		test/test_backbone_utils.py::TestFxFeatureExtraction::test_forward_backward
+		test/test_backbone_utils.py::TestFxFeatureExtraction::test_jit_forward_backward
+		test/test_models.py::test_classification_model
+		test/test_extended_models.py::TestHandleLegacyInterface::test_pretrained_pos
+		test/test_extended_models.py::TestHandleLegacyInterface::test_equivalent_behavior_weights
+		test/test_image.py::test_decode_avif[decode_avif]
+		test/test_image.py::test_decode_bad_encoded_data
+		test/test_image.py::test_decode_gif[True-earth]
+		test/test_image.py::test_decode_heic[decode_heic]
+		test/test_image.py::test_decode_webp
+		test/test_models.py::test_quantized_classification_model
+		test/test_ops.py::test_roi_opcheck
+		test/test_ops.py::TestDeformConv::test_aot_dispatch_dynamic__test_backward
+		test/test_ops.py::TestDeformConv::test_aot_dispatch_dynamic__test_forward
+	)
+	epytest
+}