diff --git a/dev-python/pycryptodome/Manifest b/dev-python/pycryptodome/Manifest
index 024ebb61ebb3d..fe6034880a8e0 100644
--- a/dev-python/pycryptodome/Manifest
+++ b/dev-python/pycryptodome/Manifest
@@ -1 +1,2 @@
 DIST pycryptodome-3.10.1.tar.gz 15545471 BLAKE2B ef1922efd0b6bef6beaee76fe03a4201a6f1cf2a203abcb12b96a5ea7c8de59a34ac704fe7508a3728a214efc0755f289d66dc14a0adb3f2eac882bc8db691bf SHA512 4c7e7e989d5363064e7e184f6b00a174045e03916cdf1199626afd7fe75eb5efcd13888ecdee607b974e96faad465694b384eb6d91edb8de1d0277ad71888c52
+DIST pycryptodome-3.10.4.tar.gz 15552675 BLAKE2B aaa6e6768d099b7b229f2b920671577800baea11b8b5a8efdd818f3d5685e46ac51d1c79d9c987f1d93cc9df98c786028137348c946da7aff35fc436ff21894c SHA512 1ee2f6c499d7ea73bdeafc94b1e91b45bf888f84ea214a01db180e030b4724264ba05e16241c465484ec13075f5300f6c489229bedb84e54b93e2852906b634f
diff --git a/dev-python/pycryptodome/pycryptodome-3.10.4.ebuild b/dev-python/pycryptodome/pycryptodome-3.10.4.ebuild
new file mode 100644
index 0000000000000..b9f61b34e0f8a
--- /dev/null
+++ b/dev-python/pycryptodome/pycryptodome-3.10.4.ebuild
@@ -0,0 +1,45 @@
+# Copyright 1999-2021 Gentoo Authors
+# Distributed under the terms of the GNU General Public License v2
+
+EAPI=8
+
+PYTHON_COMPAT=( python3_{8..10} pypy3 )
+PYTHON_REQ_USE="threads(+)"
+
+inherit distutils-r1
+
+DESCRIPTION="A self-contained cryptographic library for Python"
+HOMEPAGE="https://www.pycryptodome.org/
+	https://github.com/Legrandin/pycryptodome/
+	https://pypi.org/project/pycryptodome/"
+SRC_URI="
+	https://github.com/Legrandin/pycryptodome/archive/v${PV}.tar.gz
+		-> ${P}.tar.gz"
+
+LICENSE="BSD-2 Unlicense"
+SLOT="0"
+KEYWORDS="~alpha ~amd64 ~arm ~arm64 ~hppa ~ia64 ~mips ~ppc ~ppc64 ~riscv ~s390 ~sparc ~x86 ~amd64-linux ~x86-linux ~ppc-macos ~x64-macos ~sparc-solaris ~sparc64-solaris ~x64-solaris ~x86-solaris"
+IUSE=""
+
+DEPEND="
+	dev-libs/gmp:0=
+	>=dev-libs/libtomcrypt-1.18.2-r1:="
+BDEPEND="
+	virtual/python-cffi[${PYTHON_USEDEP}]"
+RDEPEND="
+	${DEPEND}
+	${BDEPEND}
+	!dev-python/pycrypto"
+
+PATCHES=(
+	"${FILESDIR}/pycryptodome-3.10.1-system-libtomcrypt.patch"
+)
+
+distutils_enable_tests setup.py
+
+python_prepare_all() {
+	# make sure we're unbundling it correctly
+	rm -r src/libtom || die
+
+	distutils-r1_python_prepare_all
+}