diff --git a/dev-python/jupyterlab/Manifest b/dev-python/jupyterlab/Manifest
index 3fb8abefc74aa..94ce812be1438 100644
--- a/dev-python/jupyterlab/Manifest
+++ b/dev-python/jupyterlab/Manifest
@@ -1,3 +1,4 @@
 DIST jupyterlab-4.3.7.tar.gz 21827544 BLAKE2B 6aa1886b3fa9e67c8e4978e90cf5b0e84466de15ad5dfa90c07913e1141b5c24b755f9374b34b9b9bcbd6f712f3d58b72d259e969c91263859ff7e16358a296b SHA512 57301337c8ebfc22b6ad8c09468b2f2642785967f20b74060e5ee50b0a3e1eb778f92d8179535dde5564c56b34102d096c4eee05f3fd3c6f6edbcf830f2765ed
 DIST jupyterlab-4.4.10.tar.gz 22969303 BLAKE2B 478b424ff65b4f88ee849f0e87cebf30a1a95d7da390e3179f0675c4d37cb6cc80aef0262e2e4ca09fecda71a76c6d92ed99a6b52337ff2ab22cc010122513a4 SHA512 fbdd4429ddc5c14f0085d3dc4a9cd1f93c8db3b438e62c7e653fb605819ec97f41aba182c48a54f25f5ed53d36a9137522e7901a2b36349596c8f03beeefe351
 DIST jupyterlab-4.4.9.tar.gz 22966654 BLAKE2B 9861da955decd362e983d3f1652837d8164d79656ece03c702c06044cfb566a6edc3fce1fe25270075369ef6a80fde2275e30370472eb1f362b93e6ccc093b60 SHA512 06b47a3b917bfb8e809bc9fa1ae57dddab001aac8a17da454f56f8ce23777ec71b345b4c439a9cc690bea58132a95339445ba6c6fe0e8520dc4f575fdae0a754
+DIST jupyterlab-4.5.0.tar.gz 23989880 BLAKE2B cef16c40f378421d5eaed820899ffdaa0c57f4bbf6ed730b31b2d0665afa998d2610375e06964b03f222504c09e2d1ed29ab26d953c88205bda0fb85dd49bd93 SHA512 403682e27065eb3512d3ade7579ca42551d36007af94b9e063672a52cf1e0202439888a42414363019ae9b359282466f05627f635a8140c40fc152a0123d3a68
diff --git a/dev-python/jupyterlab/jupyterlab-4.5.0.ebuild b/dev-python/jupyterlab/jupyterlab-4.5.0.ebuild
new file mode 100644
index 0000000000000..9b7eb68fa7157
--- /dev/null
+++ b/dev-python/jupyterlab/jupyterlab-4.5.0.ebuild
@@ -0,0 +1,76 @@
+# Copyright 1999-2025 Gentoo Authors
+# Distributed under the terms of the GNU General Public License v2
+
+EAPI=8
+
+DISTUTILS_USE_PEP517=hatchling
+PYTHON_COMPAT=( pypy3_11 python3_{11..13} )
+
+inherit distutils-r1 pypi xdg
+
+DESCRIPTION="JupyterLab computational environment"
+HOMEPAGE="
+	https://jupyter.org/
+	https://github.com/jupyterlab/jupyterlab/
+	https://pypi.org/project/jupyterlab/
+"
+
+LICENSE="BSD MIT GPL-3 Apache-2.0"
+SLOT="0"
+KEYWORDS="~amd64 ~arm ~arm64 ~loong ~ppc64 ~riscv ~x86"
+
+RDEPEND="
+	>=dev-python/async-lru-1.0.0[${PYTHON_USEDEP}]
+	>=dev-python/httpx-0.28.0[${PYTHON_USEDEP}]
+	>=dev-python/ipykernel-6.5.0[${PYTHON_USEDEP}]
+	>=dev-python/jinja2-3.0.3[${PYTHON_USEDEP}]
+	dev-python/jupyter-core[${PYTHON_USEDEP}]
+	>=dev-python/jupyter-lsp-2.0.0[${PYTHON_USEDEP}]
+	>=dev-python/jupyter-server-2.4.0[${PYTHON_USEDEP}]
+	<dev-python/jupyter-server-3[${PYTHON_USEDEP}]
+	>=dev-python/jupyterlab-server-2.28.0[${PYTHON_USEDEP}]
+	<dev-python/jupyterlab-server-3[${PYTHON_USEDEP}]
+	>=dev-python/notebook-shim-0.2[${PYTHON_USEDEP}]
+	dev-python/packaging[${PYTHON_USEDEP}]
+	>=dev-python/setuptools-41.1.0[${PYTHON_USEDEP}]
+	>=dev-python/tornado-6.2.0[${PYTHON_USEDEP}]
+	dev-python/traitlets[${PYTHON_USEDEP}]
+	net-libs/nodejs[npm]
+"
+
+BDEPEND="
+	dev-python/hatch-jupyter-builder[${PYTHON_USEDEP}]
+	test? (
+		dev-python/requests[${PYTHON_USEDEP}]
+		dev-python/requests-cache[${PYTHON_USEDEP}]
+		dev-python/virtualenv[${PYTHON_USEDEP}]
+	)
+"
+
+EPYTEST_DESELECT=(
+	# These tests call npm and want internet
+	jupyterlab/tests/test_jupyterlab.py::TestExtension::test_uninstall_core_extension
+	jupyterlab/tests/test_jupyterlab.py::TestExtension::test_install_and_uninstall_pinned_folder
+	jupyterlab/tests/test_jupyterlab.py::TestExtension::test_install_and_uninstall_pinned
+	jupyterlab/tests/test_jupyterlab.py::TestExtension::test_build_custom_minimal_core_config
+	jupyterlab/tests/test_jupyterlab.py::TestExtension::test_build_custom
+	jupyterlab/tests/test_jupyterlab.py::TestExtension::test_build_check
+	jupyterlab/tests/test_jupyterlab.py::TestExtension::test_build
+	jupyterlab/tests/test_build_api.py::TestBuildAPI::test_clear
+	jupyterlab/tests/test_build_api.py::TestBuildAPI::test_build
+)
+
+EPYTEST_IGNORE=(
+	jupyterlab/tests/test_announcements.py
+)
+
+EPYTEST_PLUGINS=( pytest-{console-scripts,jupyter,tornasync,timeout} )
+EPYTEST_XDIST=1
+distutils_enable_tests pytest
+# TODO: package sphinx_copybutton
+#distutils_enable_sphinx docs/source dev-python/sphinx-rtd-theme dev-python/myst-parser
+
+python_install_all() {
+	distutils-r1_python_install_all
+	mv "${ED}/usr/etc" "${ED}/etc" || die
+}