diff --git a/dev-util/roctracer/Manifest b/dev-util/roctracer/Manifest
index 7fad75ca10aa8..d6f881d68138f 100644
--- a/dev-util/roctracer/Manifest
+++ b/dev-util/roctracer/Manifest
@@ -3,3 +3,4 @@ DIST roctracer-6.1.1.tar.gz 396688 BLAKE2B e332c3a6056d1678e3da511878fd2710a4eaa
 DIST roctracer-6.3.2.tar.gz 397366 BLAKE2B 0edc2e6483935dcbc8e905b1eac1d426c3e553491cbe119a8f6cba99cadad5c622ec7a0005e27e66d57f9baf4e3048033185cd38f32b4cfd17277d80673ac225 SHA512 d08657e8424cf2fbdee1caa46140dd90f45b5efe7c71a96c789b0bb350d7c36a9c725ae436bee00fb0948ab0de5fc5356f71082619edae1316922221c19eae1c
 DIST roctracer-6.3.3.tar.gz 397370 BLAKE2B dff4c796b7284c2107ef0d308ee16d640aab6e9ce49c769a84352837f3e29e24e09e71d5a1d1fe19d22d218e607e85f7fbe6b43ff1a0a1f6e04aa859baefd054 SHA512 50ee107b7c8676dd5d41d2b9433fce701807b954b3d6624c25c32d057bd3a50ad2c7f853cb287c7bb5dd1f5fe2c3b0ec4a7cb082d5ef545c17f2ae2644c1df7c
 DIST roctracer-6.4.1.tar.gz 398019 BLAKE2B 01a280650bf0eb669c7b0eb2f0d61b05475f055ef93e1cae1e5b99ad3046392f9465026f216766d80ff47b5f387e679104f71ec7b957a15412985cf31e4ce79d SHA512 9d4e6fd3010d11c73fab7539538db56c26ebea1225082b5e9ee9bd260f087a373b0984414a8bb8174bf8b291384570255a5da9f4b5be95d5af54a6519ca8c59e
+DIST roctracer-6.4.3.tar.gz 398024 BLAKE2B bde34efb9640af84ae044a6fd507cdb1722e2f2f0610a7c1db176184c431af29f371a5d049eaa7cff5bb80e2f5db85430257d83527c11f5fde86f5f6b9442251 SHA512 c929786e2fbc34082d6d99c1f68e2ffd0eef1f9be31a6ccb385e50ec5059069b9d364f7a90301f184c966c01f9dfbd6cc6c1a4e8f5065c25d5f4d7673e42aad0
diff --git a/dev-util/roctracer/roctracer-6.4.3.ebuild b/dev-util/roctracer/roctracer-6.4.3.ebuild
new file mode 100644
index 0000000000000..e99038363fc86
--- /dev/null
+++ b/dev-util/roctracer/roctracer-6.4.3.ebuild
@@ -0,0 +1,110 @@
+# Copyright 1999-2025 Gentoo Authors
+# Distributed under the terms of the GNU General Public License v2
+
+EAPI=8
+
+PYTHON_COMPAT=( python3_{11..14} )
+ROCM_VERSION=${PV}
+
+inherit cmake flag-o-matic prefix python-any-r1 rocm toolchain-funcs
+
+DESCRIPTION="Callback/Activity Library for Performance tracing AMD GPU's"
+HOMEPAGE="https://github.com/ROCm/roctracer"
+SRC_URI="https://github.com/ROCm/roctracer/archive/rocm-${PV}.tar.gz -> ${P}.tar.gz"
+S="${WORKDIR}/roctracer-rocm-${PV}"
+
+LICENSE="MIT"
+SLOT="0/$(ver_cut 1-2)"
+KEYWORDS="~amd64"
+IUSE="test"
+RESTRICT="!test? ( test )"
+
+RDEPEND="
+	dev-util/hip:${SLOT}
+	dev-libs/rocr-runtime
+"
+DEPEND="${RDEPEND}"
+BDEPEND="
+	$(python_gen_any_dep '
+	dev-python/cppheaderparser[${PYTHON_USEDEP}]
+	dev-python/ply[${PYTHON_USEDEP}]
+	')
+"
+
+PATCHES=(
+	"${FILESDIR}/${PN}-5.7.1-with-tests.patch"
+	"${FILESDIR}/${PN}-6.3.0-fix-prettyprinter.patch"
+)
+
+python_check_deps() {
+	python_has_version "dev-python/cppheaderparser[${PYTHON_USEDEP}]" \
+		"dev-python/ply[${PYTHON_USEDEP}]"
+}
+
+pkg_setup() {
+	python-any-r1_pkg_setup
+}
+
+src_prepare() {
+	cmake_src_prepare
+
+	hprefixify script/*.py
+	eapply $(prefixify_ro "${FILESDIR}/${PN}"-5.3.3-rocm-path.patch)
+
+	# Install libs directly into /usr/lib64
+	sed -e "s:\${CMAKE_INSTALL_LIBDIR}/\${PROJECT_NAME}:\${CMAKE_INSTALL_LIBDIR}:g" \
+		-i src/CMakeLists.txt plugin/file/CMakeLists.txt || die
+
+	# Remove all install commands for tests
+	sed -E '/^ *install\(.+/d' -i test/CMakeLists.txt || die
+
+	# Test fails: https://github.com/ROCm/roctracer/issues/109
+	sed '/load_unload_reload_test/d' -i test/run.sh || die
+
+	# Fix search path for HIP cmake
+	sed -e "s,\${ROCM_PATH}/lib/cmake,/usr/$(get_libdir)/cmake,g" -i test/CMakeLists.txt || die
+
+	# bug #892732
+	sed -e 's/-Werror//' -i CMakeLists.txt || die
+
+	# libc++ may have no experimental/filesystem
+	sed -e 's|experimental/||' -e 's|experimental::||' \
+		-i plugin/file/file.cpp src/hip_stats/hip_stats.cpp \
+		src/roctracer/loader.h src/tracer_tool/tracer_tool.cpp || die
+}
+
+src_configure() {
+	rocm_use_hipcc
+
+	if [[ $(tc-get-cxx-stdlib) == "libc++" ]] ; then
+		# https://releases.llvm.org/9.0.0/projects/libcxx/docs/UsingLibcxx.html#using-filesystem
+		append-libs "-lc++fs"
+	fi
+
+	local mycmakeargs=(
+		-DCMAKE_MODULE_PATH="${EPREFIX}/usr/$(get_libdir)/cmake/hip"
+		-DFILE_REORG_BACKWARD_COMPATIBILITY=OFF
+		-DWITH_TESTS=$(usex test)
+		-DPython3_EXECUTABLE="${PYTHON}"
+	)
+	use test && mycmakeargs+=(
+		-DHIP_ROOT_DIR="${EPREFIX}/usr"
+		-DGPU_TARGETS="$(get_amdgpu_flags)"
+	)
+
+	cmake_src_configure
+}
+
+src_test() {
+	check_amdgpu
+	cd "${BUILD_DIR}" || die
+	# if LD_LIBRARY_PATH not set, dlopen cannot find correct lib
+	LD_LIBRARY_PATH="${EPREFIX}/usr/$(get_libdir):${LD_LIBRARY_PATH}" bash run.sh || die
+}
+
+src_install() {
+	cmake_src_install
+
+	# remove unneeded copy
+	rm -r "${ED}/usr/share/doc/${PF}-asan" || die
+}