diff --git a/dev-lang/ispc/Manifest b/dev-lang/ispc/Manifest
index 6c9781daedf44..2214e159cf2b2 100644
--- a/dev-lang/ispc/Manifest
+++ b/dev-lang/ispc/Manifest
@@ -1,2 +1,3 @@
 DIST ispc-1.16.1.tar.gz 19549428 BLAKE2B 742d94208d39f0560c3f2199ee06fc12f3ec2cf47c1039212219c6aa106b20cd58219e5d439c4fd1ce4a0c1a423655d0c2113a2a78152c99b4d77452171acce6 SHA512 89b844a15a888ae7074c4baa47f46d1d7176501f215c9a8c3b4bf9ad1960dc77d53f1f448d5253ad0c6a91e5088af243c3dfd148e619f9abeb6a16f715e3b463
 DIST ispc-1.17.0.tar.gz 19436681 BLAKE2B 11af6e22c4c297a2fbd0ae1bfe2a37ce2f836607b2caf42634cff0b0fe1116542e71f056de12e3472724db04f1c5174c0deb47c2bd64fb756b4bdaef48935707 SHA512 b1c67381bb8b71d268c6e68c95cc5e2d64411ce351506de96d31850b879f7777fbc1cb33f3761437f84e52ae726fabbb794ebba9cf05d5200acaca07a2ebf0ac
+DIST ispc-1.18.0.tar.gz 19469764 BLAKE2B dd95ec177120899066d5539add0f35685d73f65512e8be1cc42cf6725741d7f307fbecefc22c4944d9be0e3659d511546b15506213f3dbb97829953507996283 SHA512 350b43876d6885ab4c5c0d49c5b44323fd258d5cf7c68fcdea774baa92589542f2caeea93c347a37f0dab3dcf14e7b3e685973b41694f08ce7a2da64dc81bf06
diff --git a/dev-lang/ispc/files/ispc-1.18.0-curses-cmake.patch b/dev-lang/ispc/files/ispc-1.18.0-curses-cmake.patch
new file mode 100644
index 0000000000000..127b7095a778d
--- /dev/null
+++ b/dev-lang/ispc/files/ispc-1.18.0-curses-cmake.patch
@@ -0,0 +1,16 @@
+--- a/CMakeLists.txt
++++ b/CMakeLists.txt
+@@ -530,11 +530,8 @@ else()
+     else()
+         find_package(Curses REQUIRED)
+         find_package(ZLIB REQUIRED)
+-        if (CURSES_EXTRA_LIBRARY)
+-            # this contains the tinfo library, if found
+-            target_link_libraries(${PROJECT_NAME} ${CURSES_EXTRA_LIBRARY})
+-        endif()
+-        target_link_libraries(${PROJECT_NAME} pthread ${ZLIB_LIBRARIES} ${CURSES_CURSES_LIBRARY})
++        set(CURSES_NEED_NCURSES ON)
++        target_link_libraries(${PROJECT_NAME} pthread ${ZLIB_LIBRARIES} ${CURSES_LIBRARIES})
+     endif()
+ endif()
+ 
diff --git a/dev-lang/ispc/ispc-1.18.0.ebuild b/dev-lang/ispc/ispc-1.18.0.ebuild
new file mode 100644
index 0000000000000..47d74e37d1606
--- /dev/null
+++ b/dev-lang/ispc/ispc-1.18.0.ebuild
@@ -0,0 +1,80 @@
+# Copyright 1999-2022 Gentoo Authors
+# Distributed under the terms of the GNU General Public License v2
+
+EAPI=8
+
+PYTHON_COMPAT=( python3_{8..10} )
+LLVM_MAX_SLOT=14
+inherit cmake python-any-r1 llvm
+
+DESCRIPTION="Intel SPMD Program Compiler"
+HOMEPAGE="https://ispc.github.io/"
+
+if [[ ${PV} == 9999 ]]; then
+	inherit git-r3
+	EGIT_REPO_URI="https://github.com/ispc/ispc.git"
+else
+	SRC_URI="https://github.com/${PN}/${PN}/archive/v${PV}.tar.gz -> ${P}.tar.gz"
+	KEYWORDS="~amd64 ~arm ~arm64 ~ppc64 ~x86"
+fi
+
+LICENSE="BSD BSD-2 UoI-NCSA"
+SLOT="0"
+IUSE="examples test"
+RESTRICT="!test? ( test )"
+
+RDEPEND="<sys-devel/clang-$((${LLVM_MAX_SLOT} + 1)):="
+DEPEND="${RDEPEND}"
+BDEPEND="
+	sys-devel/bison
+	sys-devel/flex
+	${PYTHON_DEPS}
+"
+
+PATCHES=(
+	"${FILESDIR}/${PN}-9999-llvm.patch"
+	"${FILESDIR}"/ispc-1.18.0-curses-cmake.patch
+)
+
+pkg_setup() {
+	llvm_pkg_setup
+	python-any-r1_pkg_setup
+}
+
+src_prepare() {
+	if use amd64; then
+		# On amd64 systems, build system enables x86/i686 build too.
+		# This ebuild doesn't even have multilib support, nor need it.
+		# https://bugs.gentoo.org/730062
+		ewarn "Removing auto-x86 build on amd64"
+		sed -i -e 's:set(target_arch "i686"):return():' cmake/GenerateBuiltins.cmake || die
+	fi
+
+	cmake_src_prepare
+}
+
+src_configure() {
+	local mycmakeargs=(
+		-DARM_ENABLED=$(usex arm)
+		-DCMAKE_SKIP_RPATH=ON
+		-DISPC_NO_DUMPS=ON
+		-DISPC_INCLUDE_EXAMPLES=OFF
+		-DISPC_INCLUDE_TESTS=$(usex test)
+	)
+	cmake_src_configure
+}
+
+src_test() {
+	# Inject path to prevent using system ispc
+	PATH="${BUILD_DIR}/bin:${PATH}" ${EPYTHON} ./run_tests.py || die "Testing failed under ${EPYTHON}"
+}
+
+src_install() {
+	dobin "${BUILD_DIR}"/bin/ispc
+	einstalldocs
+
+	if use examples; then
+		docompress -x /usr/share/doc/${PF}/examples
+		dodoc -r examples
+	fi
+}