diff --git a/media-libs/vulkan-loader/vulkan-loader-1.1.125.ebuild b/media-libs/vulkan-loader/vulkan-loader-1.1.125.ebuild
index 3244a95630ec4..50090116171ee 100644
--- a/media-libs/vulkan-loader/vulkan-loader-1.1.125.ebuild
+++ b/media-libs/vulkan-loader/vulkan-loader-1.1.125.ebuild
@@ -52,7 +52,7 @@ multilib_src_configure() {
 		-DBUILD_WSI_WAYLAND_SUPPORT=$(usex wayland)
 		-DBUILD_WSI_XCB_SUPPORT=$(usex X)
 		-DBUILD_WSI_XLIB_SUPPORT=$(usex X)
-		-DVULKAN_HEADERS_INSTALL_DIR="/usr"
+		-DVULKAN_HEADERS_INSTALL_DIR="${EPREFIX}/usr"
 	)
 	cmake-utils_src_configure
 }
diff --git a/media-libs/vulkan-loader/vulkan-loader-1.2.133.ebuild b/media-libs/vulkan-loader/vulkan-loader-1.2.133.ebuild
index a7a9bb3c84283..60deb31aa0714 100644
--- a/media-libs/vulkan-loader/vulkan-loader-1.2.133.ebuild
+++ b/media-libs/vulkan-loader/vulkan-loader-1.2.133.ebuild
@@ -49,7 +49,7 @@ multilib_src_configure() {
 		-DBUILD_WSI_WAYLAND_SUPPORT=$(usex wayland)
 		-DBUILD_WSI_XCB_SUPPORT=$(usex X)
 		-DBUILD_WSI_XLIB_SUPPORT=$(usex X)
-		-DVULKAN_HEADERS_INSTALL_DIR="/usr"
+		-DVULKAN_HEADERS_INSTALL_DIR="${EPREFIX}/usr"
 	)
 	cmake_src_configure
 }
diff --git a/media-libs/vulkan-loader/vulkan-loader-1.2.135.ebuild b/media-libs/vulkan-loader/vulkan-loader-1.2.135.ebuild
index 1342cebbe69a9..313f090553bbf 100644
--- a/media-libs/vulkan-loader/vulkan-loader-1.2.135.ebuild
+++ b/media-libs/vulkan-loader/vulkan-loader-1.2.135.ebuild
@@ -49,7 +49,7 @@ multilib_src_configure() {
 		-DBUILD_WSI_WAYLAND_SUPPORT=$(usex wayland)
 		-DBUILD_WSI_XCB_SUPPORT=$(usex X)
 		-DBUILD_WSI_XLIB_SUPPORT=$(usex X)
-		-DVULKAN_HEADERS_INSTALL_DIR="/usr"
+		-DVULKAN_HEADERS_INSTALL_DIR="${EPREFIX}/usr"
 	)
 	cmake_src_configure
 }
diff --git a/media-libs/vulkan-loader/vulkan-loader-9999.ebuild b/media-libs/vulkan-loader/vulkan-loader-9999.ebuild
index a7a9bb3c84283..60deb31aa0714 100644
--- a/media-libs/vulkan-loader/vulkan-loader-9999.ebuild
+++ b/media-libs/vulkan-loader/vulkan-loader-9999.ebuild
@@ -49,7 +49,7 @@ multilib_src_configure() {
 		-DBUILD_WSI_WAYLAND_SUPPORT=$(usex wayland)
 		-DBUILD_WSI_XCB_SUPPORT=$(usex X)
 		-DBUILD_WSI_XLIB_SUPPORT=$(usex X)
-		-DVULKAN_HEADERS_INSTALL_DIR="/usr"
+		-DVULKAN_HEADERS_INSTALL_DIR="${EPREFIX}/usr"
 	)
 	cmake_src_configure
 }