diff --git a/profiles/default/linux/amd64/17.0/musl/clang/make.defaults b/profiles/default/linux/amd64/17.0/musl/clang/make.defaults
new file mode 100644
index 0000000000000..0733def06ac29
--- /dev/null
+++ b/profiles/default/linux/amd64/17.0/musl/clang/make.defaults
@@ -0,0 +1,6 @@
+# Copyright 2022 Gentoo Authors
+# Distributed under the terms of the GNU General Public License v2
+
+# To avoid messy ABI problems, we change the CHOST when libcxx is default.
+CHOST="x86_64-libcxx-linux-musl"
+CHOST_amd64="${CHOST}"