diff --git a/dev-python/tifffile/Manifest b/dev-python/tifffile/Manifest
new file mode 100644
index 0000000000000..e8c930b64fcda
--- /dev/null
+++ b/dev-python/tifffile/Manifest
@@ -0,0 +1 @@
+DIST tifffile-2021.11.2.gh.tar.gz 261953 BLAKE2B 039e25b173d2074b5a869394bb40cd62410b34c8a86bf047cd203aad6ab0e3217d0f4006bb092840acb314598c73619e48c66daa04c81f9965ca46b81f055d6e SHA512 5bd3340af027547bf07d78523c5c2abcecb428606d72daa446c7f3cd06f7c8da015e20cd0f4ebeb1e9a49ce0aaf6c2840170dad7a8a28e403716d4bdb1ba2238
diff --git a/dev-python/tifffile/metadata.xml b/dev-python/tifffile/metadata.xml
new file mode 100644
index 0000000000000..f3fa5ef3f3185
--- /dev/null
+++ b/dev-python/tifffile/metadata.xml
@@ -0,0 +1,11 @@
+<?xml version="1.0" encoding="UTF-8"?>
+<!DOCTYPE pkgmetadata SYSTEM "https://www.gentoo.org/dtd/metadata.dtd">
+<pkgmetadata>
+	<maintainer type="project">
+		<email>python@gentoo.org</email>
+	</maintainer>
+	<upstream>
+		<remote-id type="pypi">tifffile</remote-id>
+		<remote-id type="github">cgohlke/tifffile</remote-id>
+	</upstream>
+</pkgmetadata>
diff --git a/dev-python/tifffile/tifffile-2021.11.2.ebuild b/dev-python/tifffile/tifffile-2021.11.2.ebuild
new file mode 100644
index 0000000000000..52adc8a6887fb
--- /dev/null
+++ b/dev-python/tifffile/tifffile-2021.11.2.ebuild
@@ -0,0 +1,54 @@
+# Copyright 2021 Gentoo Authors
+# Distributed under the terms of the GNU General Public License v2
+
+EAPI=8
+
+PYTHON_COMPAT=( python3_{8..10} )
+inherit distutils-r1
+
+DESCRIPTION="Read and write TIFF files"
+HOMEPAGE="
+	https://pypi.org/project/tifffile/
+	https://github.com/cgohlke/tifffile/
+	https://www.lfd.uci.edu/~gohlke/
+"
+SRC_URI="
+	https://github.com/cgohlke/tifffile/archive/v${PV}.tar.gz
+		-> ${P}.gh.tar.gz
+"
+
+LICENSE="BSD"
+SLOT="0"
+KEYWORDS="~amd64"
+
+RDEPEND="
+	>=dev-python/numpy-1.15.1[${PYTHON_USEDEP}]
+"
+BDEPEND="
+	test? (
+		$(python_gen_cond_dep '
+			dev-python/dask[${PYTHON_USEDEP}]
+		' python3_{8..9})
+		>=dev-python/fsspec-2021.5.0[${PYTHON_USEDEP}]
+		dev-python/lxml[${PYTHON_USEDEP}]
+	)
+"
+
+distutils_enable_tests pytest
+
+EPYTEST_DESELECT=(
+	# Internet
+	tests/test_tifffile.py::test_class_omexml
+	tests/test_tifffile.py::test_class_omexml_fail
+	tests/test_tifffile.py::test_class_omexml_modulo
+	tests/test_tifffile.py::test_class_omexml_attributes
+	tests/test_tifffile.py::test_class_omexml_multiimage
+	tests/test_tifffile.py::test_write_ome
+	tests/test_tifffile.py::test_write_ome_manual
+	# requires tons of free space
+	tests/test_tifffile.py::test_write_3gb
+	tests/test_tifffile.py::test_write_bigtiff
+	'tests/test_tifffile.py::test_write_imagej_raw'
+	# requires files not in tarball (upstream misses this one in skip)
+	tests/test_tifffile.py::test_write_predictor
+)