diff --git a/dev-lang/perl/perl-5.26.2.ebuild b/dev-lang/perl/perl-5.26.2.ebuild
index 602748dc4a261..83fb285a19861 100644
--- a/dev-lang/perl/perl-5.26.2.ebuild
+++ b/dev-lang/perl/perl-5.26.2.ebuild
@@ -1,4 +1,4 @@
-# Copyright 1999-2018 Gentoo Foundation
+# Copyright 1999-2018 Gentoo Authors
 # Distributed under the terms of the GNU General Public License v2
 
 EAPI=6
@@ -331,7 +331,7 @@ src_prepare() {
 	fi
 
 	# Use errno.h from prefix rather than from host system, bug #645804
-	if use prefix && ! use prefix-guest; then
+	if use prefix && [[ -e "${EPREFIX}"/usr/include/errno.h ]] ; then
 		sed -i "/my..sysroot/s:'':'${EPREFIX}':" ext/Errno/Errno_pm.PL || die
 	fi
 
diff --git a/dev-lang/perl/perl-5.26.9999.ebuild b/dev-lang/perl/perl-5.26.9999.ebuild
index 602748dc4a261..83fb285a19861 100644
--- a/dev-lang/perl/perl-5.26.9999.ebuild
+++ b/dev-lang/perl/perl-5.26.9999.ebuild
@@ -1,4 +1,4 @@
-# Copyright 1999-2018 Gentoo Foundation
+# Copyright 1999-2018 Gentoo Authors
 # Distributed under the terms of the GNU General Public License v2
 
 EAPI=6
@@ -331,7 +331,7 @@ src_prepare() {
 	fi
 
 	# Use errno.h from prefix rather than from host system, bug #645804
-	if use prefix && ! use prefix-guest; then
+	if use prefix && [[ -e "${EPREFIX}"/usr/include/errno.h ]] ; then
 		sed -i "/my..sysroot/s:'':'${EPREFIX}':" ext/Errno/Errno_pm.PL || die
 	fi
 
diff --git a/dev-lang/perl/perl-5.28.0.ebuild b/dev-lang/perl/perl-5.28.0.ebuild
index 3fee6ac8677a3..c990d1af72b5f 100644
--- a/dev-lang/perl/perl-5.28.0.ebuild
+++ b/dev-lang/perl/perl-5.28.0.ebuild
@@ -1,4 +1,4 @@
-# Copyright 1999-2018 Gentoo Foundation
+# Copyright 1999-2018 Gentoo Authors
 # Distributed under the terms of the GNU General Public License v2
 
 EAPI=6
@@ -331,7 +331,7 @@ src_prepare() {
 	fi
 
 	# Use errno.h from prefix rather than from host system, bug #645804
-	if use prefix && ! use prefix-guest; then
+	if use prefix && [[ -e "${EPREFIX}"/usr/include/errno.h ]] ; then
 		sed -i "/my..sysroot/s:'':'${EPREFIX}':" ext/Errno/Errno_pm.PL || die
 	fi
 
diff --git a/dev-lang/perl/perl-5.28.9999.ebuild b/dev-lang/perl/perl-5.28.9999.ebuild
index 3fee6ac8677a3..c990d1af72b5f 100644
--- a/dev-lang/perl/perl-5.28.9999.ebuild
+++ b/dev-lang/perl/perl-5.28.9999.ebuild
@@ -1,4 +1,4 @@
-# Copyright 1999-2018 Gentoo Foundation
+# Copyright 1999-2018 Gentoo Authors
 # Distributed under the terms of the GNU General Public License v2
 
 EAPI=6
@@ -331,7 +331,7 @@ src_prepare() {
 	fi
 
 	# Use errno.h from prefix rather than from host system, bug #645804
-	if use prefix && ! use prefix-guest; then
+	if use prefix && [[ -e "${EPREFIX}"/usr/include/errno.h ]] ; then
 		sed -i "/my..sysroot/s:'':'${EPREFIX}':" ext/Errno/Errno_pm.PL || die
 	fi