diff --git a/dev-python/qiskit-aer/Manifest b/dev-python/qiskit-aer/Manifest
index caef656804ed1..a417a391272b3 100644
--- a/dev-python/qiskit-aer/Manifest
+++ b/dev-python/qiskit-aer/Manifest
@@ -1,2 +1,3 @@
 DIST qiskit-aer-0.16.1.gh.tar.gz 7137732 BLAKE2B 0f522bae3e2d324171bdf0a3bb8f1c99c8c1b9beac4932146dddb51616ad6b47236ffe15d533cdee64dfbd9b48ca5f24f26774e4487d2b3238f02939908b5891 SHA512 31c57ab09fecb5452205d7c8fb550384bf6e24aaa4a9665d37a7833f6353861407136f0c36fe85c8d26c386bb37b16e3298daa2c81c2aec384c69de0d3a87ee6
 DIST qiskit-aer-0.16.2.gh.tar.gz 7137908 BLAKE2B 5fe314b0dfb36a387e21f85113744b499a38ed8b52c218d8e9d47303325c541616c1cffd3a0514688809ee2949664d45b762f57bde3277abe247e02564370b1b SHA512 2a218b7da34d29b2d8628a7e819b7073bff99c396ecafa5946cc881ef73787744ee2704b33889da77eb8a92acf0ad7e96f81bbf43fc6bd71416a602049d959aa
+DIST qiskit-aer-0.16.4.gh.tar.gz 7136787 BLAKE2B b074dc088a5b26c894a5fa4ff227c9e726bd9f22265b4d1138ba944e7da5355a4715ce0ba3a5faee1752b94a74d79646277009e9f52fab882840c241f26799cc SHA512 f331cd44a59ae91aeca7af7248b1112b8a6031d8bd26f14b53d303ca94c2a9465ebfe815c59ca06ec036d8e6231b4fffdf27d5e7838dd425c0d7d84a5c5ac5d6
diff --git a/dev-python/qiskit-aer/qiskit-aer-0.16.4.ebuild b/dev-python/qiskit-aer/qiskit-aer-0.16.4.ebuild
new file mode 100644
index 0000000000000..cc789dc13a1ae
--- /dev/null
+++ b/dev-python/qiskit-aer/qiskit-aer-0.16.4.ebuild
@@ -0,0 +1,119 @@
+# Copyright 2022-2025 Gentoo Authors
+# Distributed under the terms of the GNU General Public License v2
+
+EAPI=8
+
+DISTUTILS_EXT=1
+DISTUTILS_USE_PEP517=setuptools
+PYTHON_COMPAT=( python3_{10..13} )
+
+inherit distutils-r1
+
+DESCRIPTION="High performance simulator for quantum circuits that includes noise models"
+HOMEPAGE="
+	https://github.com/Qiskit/qiskit-aer/
+	https://pypi.org/project/qiskit-aer/
+"
+SRC_URI="
+	https://github.com/Qiskit/qiskit-aer/archive/${PV}.tar.gz
+		-> ${P}.gh.tar.gz
+"
+
+LICENSE="Apache-2.0"
+SLOT="0"
+KEYWORDS="~amd64"
+
+# The reference implementation of BLAS/CBLAS is not compatible with qiskit-aer right now,
+# because importing library causes an error.
+# /usr/lib/python3.9/site-packages/qiskit/providers/aer/backends/controller_wrappers.cpython-39-x86_64-linux-gnu.so: undefined symbol: slamch_
+# Using sci-libs/openblas instead here,
+# with the option to switch between reference/openblas implementation runtime (eselect-ldso).
+#
+# <nlohmann_json-3.10.3 for https://github.com/Qiskit/qiskit-aer/issues/1742
+DEPEND="
+	>=dev-python/numpy-1.16.3[${PYTHON_USEDEP}]
+	<dev-cpp/nlohmann_json-3.10.3
+	>=dev-cpp/nlohmann_json-3.1.1
+	>=dev-libs/spdlog-1.9.2:=
+	>=dev-cpp/muParserX-4.0.8
+	virtual/cblas[eselect-ldso]
+	sci-libs/openblas[eselect-ldso]
+"
+RDEPEND="
+	${DEPEND}
+	>=dev-python/psutil-5[${PYTHON_USEDEP}]
+	>=dev-python/qiskit-1.1.0[${PYTHON_USEDEP}]
+	>=dev-python/scipy-1.0[${PYTHON_USEDEP}]
+"
+BDEPEND="
+	>=dev-build/cmake-3.17
+	>=dev-python/scikit-build-0.11.0[${PYTHON_USEDEP}]
+	>=dev-python/pybind11-2.6[${PYTHON_USEDEP}]
+	test? (
+		dev-python/ddt[${PYTHON_USEDEP}]
+		dev-python/fixtures[${PYTHON_USEDEP}]
+	)
+"
+
+EPYTEST_XDIST=1
+distutils_enable_tests pytest
+
+check_openblas() {
+	local libdir=$(get_libdir) me="openblas"
+
+	# check blas
+	local current_blas=$(eselect blas show ${libdir} | cut -d' ' -f2)
+	if [[ ${current_blas} != "${me}" ]]; then
+		eerror "Current eselect: BLAS/CBLAS ($libdir) -> [${current_blas}]."
+		eerror "To use qiskit-aer, you have to issue (as root):"
+		eerror "\t eselect blas set ${libdir} ${me}"
+		return 1
+	fi
+	return 0
+}
+
+pkg_setup() {
+	if use test; then
+		check_openblas
+		if [[ $? -ne 0 ]]; then
+			die "Set blas implementation to openblas using 'eselect blas set openblas'!"
+		fi
+	fi
+}
+
+python_prepare_all() {
+	export DISABLE_CONAN="ON"
+	export DISABLE_DEPENDENCY_INSTALL="ON"
+	export SKBUILD_CONFIGURE_OPTIONS="-DTEST_JSON=1"
+
+	distutils-r1_python_prepare_all
+}
+
+python_test() {
+	local EPYTEST_DESELECT=(
+		# requires qiskit_qasm3_import
+		test/terra/backends/aer_simulator/test_save_statevector.py::TestSaveStatevector::test_save_statevector_for_qasm3_circuit_1___automatic____CPU__
+		test/terra/backends/aer_simulator/test_save_statevector.py::TestSaveStatevector::test_save_statevector_for_qasm3_circuit_2___statevector____CPU__
+		test/terra/backends/aer_simulator/test_save_statevector.py::TestSaveStatevector::test_save_statevector_for_qasm3_circuit_3___matrix_product_state____CPU__
+		test/terra/backends/aer_simulator/test_save_statevector.py::TestSaveStatevector::test_save_statevector_for_qasm3_circuit_4___extended_stabilizer____CPU__
+	)
+
+	local EPYTEST_IGNORE=(
+		# TODO: qiskit.providers.aer? wtf?
+		test/terra/expression/test_classical_expressions.py
+	)
+
+	# From tox.ini/tests.yml in CI
+	# Needed to suppress a warning in jupyter-core 5.x by eagerly migrating to
+	# a new internal interface that will be the default in jupyter-core 6.x.
+	# This variable should become redundant on release of jupyter-core 6.
+	local -x JUPYTER_PLATFORM_DIRS=1
+
+	rm -rf qiskit_aer || die
+	local -x PYTEST_DISABLE_PLUGIN_AUTOLOAD=1
+	epytest -s
+}
+
+pkg_postinst() {
+	check_openblas
+}