diff --git a/dev-ml/cstruct/Manifest b/dev-ml/cstruct/Manifest
deleted file mode 100644
index 0fe7a4ca89055..0000000000000
--- a/dev-ml/cstruct/Manifest
+++ /dev/null
@@ -1 +0,0 @@
-DIST cstruct-v5.2.0.tbz 227195 BLAKE2B 21eb94d0bbfb6f633f37ed7d6db716f7011765219f98f437d1c4ba4778e5d71fce37db1523d5f940d784779dfae1cccda7c521c5b3a2f46048d136a069d1099e SHA512 4e8cb53801980dacb9c9153bada89557ffcd9afaac262592fe6243bec3e76d5d1cfe3babe133a9a32e35ed00d98a4b54d55403e8505cca6a1328be50fadb5f37
diff --git a/dev-ml/cstruct/cstruct-5.2.0.ebuild b/dev-ml/cstruct/cstruct-5.2.0.ebuild
deleted file mode 100644
index f2b874f5dceb4..0000000000000
--- a/dev-ml/cstruct/cstruct-5.2.0.ebuild
+++ /dev/null
@@ -1,24 +0,0 @@
-# Copyright 1999-2021 Gentoo Authors
-# Distributed under the terms of the GNU General Public License v2
-
-EAPI=7
-
-inherit dune
-
-MYP=${PN}-v${PV}
-
-DESCRIPTION="Map OCaml arrays onto C-like structs"
-HOMEPAGE="https://github.com/mirage/ocaml-cstruct https://mirage.io"
-SRC_URI="https://github.com/mirage/ocaml-${PN}/releases/download/v${PV}/${MYP}.tbz"
-
-LICENSE="ISC"
-SLOT="0/${PV}"
-KEYWORDS="~amd64"
-IUSE="+ocamlopt"
-
-RDEPEND="dev-ml/async_unix:=
-	dev-ml/bigarray-compat:=
-	>=dev-ml/ppx_tools_versioned-5.4.0:="
-DEPEND="${RDEPEND}"
-
-S="${WORKDIR}"/${MYP}
diff --git a/dev-ml/cstruct/metadata.xml b/dev-ml/cstruct/metadata.xml
deleted file mode 100644
index 3f974fc39b866..0000000000000
--- a/dev-ml/cstruct/metadata.xml
+++ /dev/null
@@ -1,11 +0,0 @@
-<?xml version="1.0" encoding="UTF-8"?>
-<!DOCTYPE pkgmetadata SYSTEM "http://www.gentoo.org/dtd/metadata.dtd">
-<pkgmetadata>
-	<maintainer type="project">
-		<email>ml@gentoo.org</email>
-		<name>ML</name>
-	</maintainer>
-	<upstream>
-		<remote-id type="github">mirage/ocaml-cstruct</remote-id>
-	</upstream>
-</pkgmetadata>
diff --git a/profiles/package.mask b/profiles/package.mask
index 3456a2bc25fae..e75bf562bc485 100644
--- a/profiles/package.mask
+++ b/profiles/package.mask
@@ -356,11 +356,6 @@ sys-kernel/bliss-kernel-bin
 # Removal in 30 days (2021-08-22)
 www-servers/resin
 
-# Alfredo Tupone <tupone@gentoo.org> (2021-07-23)
-# Requirements conflicts so it is not buildable
-# No revdep. Retire in 30 days (2021-08-22)
-dev-ml/cstruct
-
 # Andrew Ammerlaan <andrewammerlaan@gentoo.org> (2021-07-12)
 # Version 3.3.0 suffers from ridiculously high CPU usage, this version has
 # therefore been retracted upstream.