diff --git a/sci-libs/hipRAND/Manifest b/sci-libs/hipRAND/Manifest
index 7e56e93f519f2..b22fbe7004d2b 100644
--- a/sci-libs/hipRAND/Manifest
+++ b/sci-libs/hipRAND/Manifest
@@ -3,3 +3,4 @@ DIST hipRAND-rocm-6.1.1.tar.gz 119063 BLAKE2B dc314d8b09c15351075594335d14f65024
 DIST hipRAND-rocm-6.3.2.tar.gz 125506 BLAKE2B 836eb474c4b88a4729e3e9176736b28c090cf2add0ef463bf594deede353b755a1a07ef5898ec51e3ae66c2972cbfe6a71815020dd5f3e3b1aca105d8d8ca8e2 SHA512 8f3893ec89f76b859847b75acf3ec20f751924cd16d3ea25dbb0e1f2a5b7d75832c214e6ce9e180e3f74fbcb0c4bf95b75bf3ad32e9ac34e5e0f7522554f38a6
 DIST hipRAND-rocm-6.3.3.tar.gz 125512 BLAKE2B 3a1c5fbdc115e6372dd88501abebab729022fcda03c9a3a39848fdce15f335abd772f82660af09c48abe9b88f138866a31273f5ee2b4290400ecf8cc3f8e2456 SHA512 ee2e4364d07e7ed3515f3c1094119e54055d052e396b5dece738241c8404eecb75e737f43e513262474140c78046430ea5d7f3d915c321c5d9ba4b20778ccc6e
 DIST hipRAND-rocm-6.4.1.tar.gz 126535 BLAKE2B 54e241cd63da3ed1ed9b6bbe6b2878092163acb5b69ceebff3fc04a94f1d0977bb2131051f6b01937ad318c3b04a6b992d5c7be42a74c37a58a585d6de61d24d SHA512 99b15b6e7aa46ad7928514cb75631fecbd85cc5af21e972249e309a00656e05048c8483a34d7151fa9b40caa4ac48953ed6c40755ff7e009d81dae46d184dfd7
+DIST hipRAND-rocm-6.4.3.tar.gz 127204 BLAKE2B 40751993b2b6567326e9e69ff006d5c1b7653e9cc1fa7d71307d9d41e91a3e4ce7d3767fd03ebde52afacf6be22d371a3273a7ca45e2c6a9a11fd772bc6256e6 SHA512 22cd2396723292ccb7504b4c5ce4150d1fe04dcfaf020963d28c27077e001fc9edf23fa03d18159fecc4f1d51df300a04a8297dfec62476464e93a7bbafc9f9b
diff --git a/sci-libs/hipRAND/hipRAND-6.4.3.ebuild b/sci-libs/hipRAND/hipRAND-6.4.3.ebuild
new file mode 100644
index 0000000000000..1ee1fed9a8825
--- /dev/null
+++ b/sci-libs/hipRAND/hipRAND-6.4.3.ebuild
@@ -0,0 +1,38 @@
+# Copyright 1999-2025 Gentoo Authors
+# Distributed under the terms of the GNU General Public License v2
+
+EAPI=8
+
+ROCM_VERSION=${PV}
+
+inherit cmake rocm
+
+DESCRIPTION="CU / ROCM agnostic hip RAND implementation"
+HOMEPAGE="https://github.com/ROCm/hipRAND"
+SRC_URI="https://github.com/ROCm/hipRAND/archive/refs/tags/rocm-${PV}.tar.gz -> hipRAND-rocm-${PV}.tar.gz"
+S="${WORKDIR}/hipRAND-rocm-${PV}"
+
+REQUIRED_USE="${ROCM_REQUIRED_USE}"
+
+LICENSE="MIT"
+SLOT="0/$(ver_cut 1-2)"
+KEYWORDS="~amd64"
+
+RESTRICT="test"
+
+RDEPEND="dev-util/hip
+	sci-libs/rocRAND:${SLOT}"
+DEPEND="${RDEPEND}"
+
+src_configure() {
+	rocm_use_hipcc
+
+	local mycmakeargs=(
+		-Wno-dev
+		-DAMDGPU_TARGETS="$(get_amdgpu_flags)"
+		-DBUILD_FILE_REORG_BACKWARD_COMPATIBILITY=OFF
+		-DROCM_SYMLINK_LIBS=OFF
+	)
+
+	cmake_src_configure
+}