diff --git a/virtual/os-headers/os-headers-0-r1.ebuild b/virtual/os-headers/os-headers-0-r1.ebuild
index 1c5db1ee456ab..be7781981271d 100644
--- a/virtual/os-headers/os-headers-0-r1.ebuild
+++ b/virtual/os-headers/os-headers-0-r1.ebuild
@@ -18,4 +18,8 @@ RDEPEND="
 			)
 			!prefix? ( sys-freebsd/freebsd-lib )
 		)
+	)
+	prefix-guest? (
+		!sys-kernel/linux-headers
+		!sys-freebsd/freebsd-lib
 	)"