diff --git a/sci-libs/hipBLAS/Manifest b/sci-libs/hipBLAS/Manifest
index b072b8b866c18..fb7327a5aa828 100644
--- a/sci-libs/hipBLAS/Manifest
+++ b/sci-libs/hipBLAS/Manifest
@@ -3,3 +3,4 @@ DIST hipBLAS-6.1.1.tar.gz 835570 BLAKE2B dc8a54f3b6c780f63e57f208d67b15e965d3a7c
 DIST hipBLAS-6.3.2.tar.gz 993139 BLAKE2B a053f8b54318a169518f084e0bca3c9272cb51fab564c8d874b19483232cfeacb92707ad5224f4d0c3848b52d82973c36f0d4fdb429c9f5d995b3c56b1194075 SHA512 8581905a923484662471da786b795d7f960b45cc5eed991b101a88a4e3d4ea5217582c813192dde8eb35eafba9867c3ac448aeb4d7ef470e6da544f09397d902
 DIST hipBLAS-6.3.3.tar.gz 993121 BLAKE2B 7cfe71112a8083a0f5fd1f2629bde12a79b13f2d289dd82405978f7713fb30b132d002d01566b077650265e8ee6746b51e4e3defb92bd1416ec83ce7c490407c SHA512 a14ba19557236ef8affa557d5139c6c380120a68eac5d6b7172b279380a52be4d451a3c2a7ee2a7e4d169c16081ea4639dc058b5231d2a33429fb0f065db5b18
 DIST hipBLAS-6.4.1.tar.gz 993764 BLAKE2B 568872d3d7b4a38881a278966b320186d90065ffa657b54e1704c0ca7458f9b29e50412e45e5cefc1a209d3049aa1c809705e563e9ed5959c1fd066fb64a494f SHA512 192b24e53e4e0c3d4495e5444024022495bb35f3a60275d638541026deaa3ce37e4611c9355bd10cb1825354f5a411331475a34f8cc15a1fb10619591dee5e9c
+DIST hipBLAS-6.4.3.tar.gz 993780 BLAKE2B 6c2e88a1d4d313a39abbaaf663b0d83aaf5dbf4f7e625d97189cd98302a544f4c7d617fcc1ec2a2918edaff08f34329be0b6657c1aba3fa35a26ac919c31b85c SHA512 5ce1825624a267a1af25b1eafb6f3bd2bbbb9c9a6ce2d7788a2cf3213174e59d0b04599a89f4ba8b796cba1c8fc5cf5d2f9820fd948b735da781fe6d04c2826e
diff --git a/sci-libs/hipBLAS/hipBLAS-6.4.3.ebuild b/sci-libs/hipBLAS/hipBLAS-6.4.3.ebuild
new file mode 100644
index 0000000000000..608abc3be9192
--- /dev/null
+++ b/sci-libs/hipBLAS/hipBLAS-6.4.3.ebuild
@@ -0,0 +1,46 @@
+# Copyright 1999-2025 Gentoo Authors
+# Distributed under the terms of the GNU General Public License v2
+
+EAPI=8
+
+ROCM_VERSION=${PV}
+
+inherit cmake rocm
+DESCRIPTION="ROCm BLAS marshalling library"
+HOMEPAGE="https://github.com/ROCm/hipBLAS"
+SRC_URI="https://github.com/ROCm/hipBLAS/archive/rocm-${PV}.tar.gz -> ${P}.tar.gz"
+S="${WORKDIR}/hipBLAS-rocm-${PV}"
+
+REQUIRED_USE="${ROCM_REQUIRED_USE}"
+
+LICENSE="MIT"
+SLOT="0/$(ver_cut 1-2)"
+KEYWORDS="~amd64"
+
+RDEPEND="
+	dev-util/hip:${SLOT}
+	sci-libs/hipBLAS-common:${SLOT}
+	sci-libs/rocBLAS:${SLOT}
+	sci-libs/rocSOLVER:${SLOT}
+"
+DEPEND="${RDEPEND}"
+
+PATCHES=(
+	"${FILESDIR}"/${PN}-6.3.0-no-git.patch
+)
+
+src_configure() {
+	# Note: hipcc is enforced; clang fails when libc++ is enabled
+	# with an error similar to https://github.com/boostorg/config/issues/392
+	rocm_use_hipcc
+
+	local mycmakeargs=(
+		# currently hipBLAS is a wrapper of rocBLAS which has tests, so no need to perform test here
+		-DBUILD_CLIENTS_TESTS=OFF
+		-DBUILD_CLIENTS_BENCHMARKS=OFF
+		-DBUILD_FILE_REORG_BACKWARD_COMPATIBILITY=OFF
+		-DROCM_SYMLINK_LIBS=OFF
+	)
+
+	cmake_src_configure
+}