diff --git a/dev-python/pycryptodome/Manifest b/dev-python/pycryptodome/Manifest
index d2a7e81bf0fa3..540fe06bd9d69 100644
--- a/dev-python/pycryptodome/Manifest
+++ b/dev-python/pycryptodome/Manifest
@@ -1,2 +1 @@
-DIST pycryptodome-3.21.0.gh.tar.gz 17464067 BLAKE2B 5fcf62317053ae3d1dddd90bb223e9866944b4c4325ae146c17c48d2345c06c3fc9951dc72c135ec5a61043b7eced92b69c9bc5f43d47e1f512b9c9ce94fa310 SHA512 cfb66b1e53547992b9405bc6a2d90ed3bc3d1857a01ef619069b9d1aa24d809a9d46d8b0d824999588dd6c0de9a5e39db70b572a9954f0ead0dd39f9b7cedbcc
 DIST pycryptodome-3.22.0.gh.tar.gz 19700949 BLAKE2B 381aec9085ce2e54dd99061b5966409aca4e0da4315c0e7234f7620438cfbec303d1914ddc20ac529a5504bbdb3354976e56f0cb9c37030da142da33bf620798 SHA512 e997b4ffa2d003bfcd4b53af58d18e07db5aee4fea539f76c3b13c2ed92a9067d73f5bdfd19c649a2584ef143a918e9905f10e6d57a927a5d50ce19e5e95268f
diff --git a/dev-python/pycryptodome/pycryptodome-3.21.0.ebuild b/dev-python/pycryptodome/pycryptodome-3.21.0.ebuild
deleted file mode 100644
index 076b0a12b9cc2..0000000000000
--- a/dev-python/pycryptodome/pycryptodome-3.21.0.ebuild
+++ /dev/null
@@ -1,60 +0,0 @@
-# Copyright 1999-2025 Gentoo Authors
-# Distributed under the terms of the GNU General Public License v2
-
-EAPI=8
-
-DISTUTILS_EXT=1
-DISTUTILS_USE_PEP517=setuptools
-PYTHON_COMPAT=( python3_{10..13} pypy3 pypy3_11 )
-PYTHON_REQ_USE="threads(+)"
-
-inherit distutils-r1
-
-DESCRIPTION="A self-contained cryptographic library for Python"
-HOMEPAGE="
-	https://www.pycryptodome.org/
-	https://github.com/Legrandin/pycryptodome/
-	https://pypi.org/project/pycryptodome/
-"
-SRC_URI="
-	https://github.com/Legrandin/pycryptodome/archive/v${PV}.tar.gz
-		-> ${P}.gh.tar.gz
-"
-
-LICENSE="BSD-2 Unlicense"
-SLOT="0"
-KEYWORDS="~alpha amd64 arm arm64 ~hppa ~loong ~m68k ~mips ppc ppc64 ~riscv ~s390 sparc x86 ~amd64-linux ~x86-linux ~arm64-macos ~ppc-macos ~x64-macos ~x64-solaris"
-
-DEPEND="
-	dev-libs/gmp:=
-	>=dev-libs/libtomcrypt-1.18.2-r1:=
-"
-BDEPEND="
-	$(python_gen_cond_dep 'dev-python/cffi[${PYTHON_USEDEP}]' 'python*')
-"
-RDEPEND="
-	${DEPEND}
-	${BDEPEND}
-"
-
-PATCHES=(
-	"${FILESDIR}/pycryptodome-3.10.1-system-libtomcrypt.patch"
-)
-
-python_prepare_all() {
-	# make sure we're unbundling it correctly
-	rm -r src/libtom || die
-
-	distutils-r1_python_prepare_all
-}
-
-python_test() {
-	local -x PYTHONPATH=${S}/test_vectors:${PYTHONPATH}
-	"${EPYTHON}" - <<-EOF || die
-		import sys
-		from Crypto import SelfTest
-		SelfTest.run(verbosity=2, stream=sys.stdout)
-	EOF
-
-	# TODO: run cmake tests from src/test?
-}