diff --git a/profiles/base/use.mask b/profiles/base/use.mask
index 46ecbaaeb637e..e4880f857842c 100644
--- a/profiles/base/use.mask
+++ b/profiles/base/use.mask
@@ -11,6 +11,7 @@ ruby_targets_ruby31
 
 # Michał Górny <mgorny@gentoo.org> (2024-12-31)
 # LLVM slots with no keyworded releases yet.
+llvm_slot_22
 llvm_slot_21
 
 # Andreas Sturmlechner <asturm@gentoo.org> (2024-12-11)
diff --git a/profiles/base/use.stable.mask b/profiles/base/use.stable.mask
index ad77e0d837674..ac29d2e0b84b6 100644
--- a/profiles/base/use.stable.mask
+++ b/profiles/base/use.stable.mask
@@ -10,6 +10,7 @@ ada_target_gcc_15
 
 # Michał Górny <mgorny@gentoo.org> (2024-12-31)
 # LLVM slots with no stable releases yet.
+llvm_slot_22
 llvm_slot_21
 
 # Hans de Graaff <graaff@gentoo.org> (2024-12-26)
diff --git a/profiles/desc/llvm_slot.desc b/profiles/desc/llvm_slot.desc
index 5c5beb941f57a..360d6e6eab6c1 100644
--- a/profiles/desc/llvm_slot.desc
+++ b/profiles/desc/llvm_slot.desc
@@ -8,3 +8,4 @@
 19 - Use LLVM 19.
 20 - Use LLVM 20.
 21 - Use LLVM 21.
+22 - Use LLVM 22.