diff --git a/gui-libs/gtk/gtk-4.14.4-r1.ebuild b/gui-libs/gtk/gtk-4.14.4-r1.ebuild
index 09c6be8ffc7ee..7627347f4fe77 100644
--- a/gui-libs/gtk/gtk-4.14.4-r1.ebuild
+++ b/gui-libs/gtk/gtk-4.14.4-r1.ebuild
@@ -3,7 +3,7 @@
 
 EAPI=8
 PYTHON_COMPAT=( python3_{10..13} )
-inherit gnome.org gnome2-utils meson optfeature python-any-r1 toolchain-funcs virtualx xdg
+inherit flag-o-matic gnome.org gnome2-utils meson optfeature python-any-r1 toolchain-funcs virtualx xdg
 
 DESCRIPTION="GTK is a multi-platform toolkit for creating graphical user interfaces"
 HOMEPAGE="https://www.gtk.org/ https://gitlab.gnome.org/GNOME/gtk/"
@@ -146,6 +146,8 @@ src_prepare() {
 }
 
 src_configure() {
+	use x86 && append-flags -DDISABLE_X64=1 #943705 https://gitlab.gnome.org/GNOME/gtk/-/issues/4173
+
 	local emesonargs=(
 		# GDK backends
 		$(meson_use X x11-backend)
diff --git a/gui-libs/gtk/gtk-4.16.12-r1.ebuild b/gui-libs/gtk/gtk-4.16.12-r1.ebuild
index 96a2b4956b1a7..e1f2c6fa2d969 100644
--- a/gui-libs/gtk/gtk-4.16.12-r1.ebuild
+++ b/gui-libs/gtk/gtk-4.16.12-r1.ebuild
@@ -3,7 +3,7 @@
 
 EAPI=8
 PYTHON_COMPAT=( python3_{10..13} )
-inherit gnome.org gnome2-utils meson optfeature python-any-r1 toolchain-funcs virtualx xdg
+inherit flag-o-matic gnome.org gnome2-utils meson optfeature python-any-r1 toolchain-funcs virtualx xdg
 
 DESCRIPTION="GTK is a multi-platform toolkit for creating graphical user interfaces"
 HOMEPAGE="https://www.gtk.org/ https://gitlab.gnome.org/GNOME/gtk/"
@@ -146,6 +146,8 @@ src_prepare() {
 }
 
 src_configure() {
+	use x86 && append-flags -DDISABLE_X64=1 #943705 https://gitlab.gnome.org/GNOME/gtk/-/issues/4173
+
 	local emesonargs=(
 		# GDK backends
 		$(meson_use X x11-backend)
diff --git a/gui-libs/gtk/gtk-4.16.13.ebuild b/gui-libs/gtk/gtk-4.16.13.ebuild
index df0eb307fe710..ca0e6a05fea0e 100644
--- a/gui-libs/gtk/gtk-4.16.13.ebuild
+++ b/gui-libs/gtk/gtk-4.16.13.ebuild
@@ -3,7 +3,7 @@
 
 EAPI=8
 PYTHON_COMPAT=( python3_{10..13} )
-inherit gnome.org gnome2-utils meson optfeature python-any-r1 toolchain-funcs virtualx xdg
+inherit flag-o-matic gnome.org gnome2-utils meson optfeature python-any-r1 toolchain-funcs virtualx xdg
 
 DESCRIPTION="GTK is a multi-platform toolkit for creating graphical user interfaces"
 HOMEPAGE="https://www.gtk.org/ https://gitlab.gnome.org/GNOME/gtk/"
@@ -146,6 +146,8 @@ src_prepare() {
 }
 
 src_configure() {
+	use x86 && append-flags -DDISABLE_X64=1 #943705 https://gitlab.gnome.org/GNOME/gtk/-/issues/4173
+
 	local emesonargs=(
 		# GDK backends
 		$(meson_use X x11-backend)
diff --git a/gui-libs/gtk/gtk-4.18.5.ebuild b/gui-libs/gtk/gtk-4.18.5.ebuild
index 006d8883cafae..16cc39003920c 100644
--- a/gui-libs/gtk/gtk-4.18.5.ebuild
+++ b/gui-libs/gtk/gtk-4.18.5.ebuild
@@ -3,7 +3,7 @@
 
 EAPI=8
 PYTHON_COMPAT=( python3_{11..13} )
-inherit gnome.org gnome2-utils meson optfeature python-any-r1 toolchain-funcs virtualx xdg
+inherit flag-o-matic gnome.org gnome2-utils meson optfeature python-any-r1 toolchain-funcs virtualx xdg
 
 DESCRIPTION="GTK is a multi-platform toolkit for creating graphical user interfaces"
 HOMEPAGE="https://www.gtk.org/ https://gitlab.gnome.org/GNOME/gtk/"
@@ -145,6 +145,8 @@ src_prepare() {
 }
 
 src_configure() {
+	use x86 && append-flags -DDISABLE_X64=1 #943705 https://gitlab.gnome.org/GNOME/gtk/-/issues/4173
+
 	local emesonargs=(
 		# GDK backends
 		$(meson_use X x11-backend)
diff --git a/gui-libs/gtk/gtk-4.18.6.ebuild b/gui-libs/gtk/gtk-4.18.6.ebuild
index ee7dfc19898a0..227be1aec2579 100644
--- a/gui-libs/gtk/gtk-4.18.6.ebuild
+++ b/gui-libs/gtk/gtk-4.18.6.ebuild
@@ -3,7 +3,7 @@
 
 EAPI=8
 PYTHON_COMPAT=( python3_{11..14} )
-inherit gnome.org gnome2-utils meson optfeature python-any-r1 toolchain-funcs virtualx xdg
+inherit flag-o-matic gnome.org gnome2-utils meson optfeature python-any-r1 toolchain-funcs virtualx xdg
 
 DESCRIPTION="GTK is a multi-platform toolkit for creating graphical user interfaces"
 HOMEPAGE="https://www.gtk.org/ https://gitlab.gnome.org/GNOME/gtk/"
@@ -145,6 +145,8 @@ src_prepare() {
 }
 
 src_configure() {
+	use x86 && append-flags -DDISABLE_X64=1 #943705 https://gitlab.gnome.org/GNOME/gtk/-/issues/4173
+
 	local emesonargs=(
 		# GDK backends
 		$(meson_use X x11-backend)