diff --git a/gnome-extra/gnome-tweaks/Manifest b/gnome-extra/gnome-tweaks/Manifest
index 8c908523e5e96..b060cf39675e9 100644
--- a/gnome-extra/gnome-tweaks/Manifest
+++ b/gnome-extra/gnome-tweaks/Manifest
@@ -1 +1,2 @@
 DIST gnome-tweaks-46.1.tar.xz 691844 BLAKE2B ffb2522139bb96a48aacaedd713d3bd8c3e2fc87416e6ca66e71d856996364e32cc2417ab71119903f175e42c060fb46405aaf47fd34222cc4b853cfb82bac84 SHA512 8e167a84cc2eb700fe098cf7221bb3f8a3cc039826e1267e5585b5362862e4626dea3c84dfb8ccc9d08b34d2894422ca8505623148415116423738d2c07956f3
+DIST gnome-tweaks-49.0.tar.xz 695716 BLAKE2B 49d1075a619f02fee42f5d7857db62f8336a10b417a5f513c6c6e97ddbea0185fdd9df6a54283b72e1d963027cd09f4488f49f8461764f5d1679cbfc928bc79c SHA512 ec07fbc8c1b24b5366e80aa3b4d795633616703994bfd5785b1691a84d53f5419d9494142143b31fc0dd448be3968c4b300adefdc2239f9e99ccd3955c8691ff
diff --git a/gnome-extra/gnome-tweaks/gnome-tweaks-49.0.ebuild b/gnome-extra/gnome-tweaks/gnome-tweaks-49.0.ebuild
new file mode 100644
index 0000000000000..af89636948024
--- /dev/null
+++ b/gnome-extra/gnome-tweaks/gnome-tweaks-49.0.ebuild
@@ -0,0 +1,56 @@
+# Copyright 1999-2025 Gentoo Authors
+# Distributed under the terms of the GNU General Public License v2
+
+EAPI=8
+PYTHON_COMPAT=( python3_{11..14} )
+
+inherit gnome.org gnome2-utils meson python-single-r1 xdg
+
+DESCRIPTION="Customize advanced GNOME options"
+HOMEPAGE="https://gitlab.gnome.org/GNOME/gnome-tweaks"
+
+LICENSE="GPL-3+ CC0-1.0"
+SLOT="0"
+
+REQUIRED_USE="${PYTHON_REQUIRED_USE}"
+
+KEYWORDS="~amd64 ~arm ~arm64 ~loong ~ppc64 ~riscv ~x86"
+
+DEPEND="${PYTHON_DEPS}"
+# See README.md for list of deps
+RDEPEND="${DEPEND}
+	$(python_gen_cond_dep '
+		>=dev-python/pygobject-3.46.0:3[${PYTHON_USEDEP}]
+	')
+	>=gnome-base/gnome-settings-daemon-3
+	x11-themes/sound-theme-freedesktop
+
+	>=dev-libs/glib-2.78:2
+	>=dev-libs/gobject-introspection-1.82.0-r2
+	>=gui-libs/gtk-4.10.0:4[introspection]
+	>=gui-libs/libadwaita-1.4.0:1[introspection]
+	>=dev-libs/libgudev-238[introspection]
+	gnome-base/gnome-desktop:4
+	x11-libs/libnotify[introspection]
+	x11-libs/pango[introspection]
+	>=gnome-base/gsettings-desktop-schemas-46.0[introspection]
+	>=gnome-base/gnome-shell-3.24
+	x11-wm/mutter
+"
+BDEPEND=">=sys-devel/gettext-0.19.8"
+
+src_install() {
+	meson_src_install
+	python_optimize
+	python_fix_shebang "${ED}"/usr/bin/
+}
+
+pkg_postinst() {
+	xdg_pkg_postinst
+	gnome2_schemas_update
+}
+
+pkg_postrm() {
+	xdg_pkg_postrm
+	gnome2_schemas_update
+}