diff --git a/profiles/package.mask b/profiles/package.mask
index 748fe1cdd1d18..e6ef9622eef7d 100644
--- a/profiles/package.mask
+++ b/profiles/package.mask
@@ -381,13 +381,6 @@ app-text/goldendict
 # Removal in 30 days.  Bug #721990.
 media-video/cinelerra
 
-# Aisha Tammy <gentoo@aisha.cc> (2020-11-13)
-# dead packages with latest releases before 2013
-# these are superseded by other scikit packages
-# scikit-optimize, sktime
-# Removal in 30 days (Bug #749297)
-sci-libs/scikits_optimization
-
 # Jonas Stein <jstein@gentoo.org> (2020-11-12)
 # Adobe will stop distributing Flash Player after 2020-12-31.
 # Masked for removal after 2020-12-31
diff --git a/sci-libs/scikits_optimization/Manifest b/sci-libs/scikits_optimization/Manifest
deleted file mode 100644
index 402b40290eb67..0000000000000
--- a/sci-libs/scikits_optimization/Manifest
+++ /dev/null
@@ -1 +0,0 @@
-DIST scikits.optimization-0.3.tar.gz 25297 BLAKE2B 1001ee772fb115e620f98547332f26f3876b38c9718e9f3c9a47e17863f2efbd6d9f6551da2340fda1ce612b385f757123bd32786764dcd3e287689313cac4ec SHA512 e8f33f4770d9b0514854e36127c53554823a159363c69d1ca0445a05ca9ebc55bc7105b35b2c615bfbef0c63a2b658d628befccb0ab09bcf98d91f8cb4d8be72
diff --git a/sci-libs/scikits_optimization/metadata.xml b/sci-libs/scikits_optimization/metadata.xml
deleted file mode 100644
index 108897ac87a1c..0000000000000
--- a/sci-libs/scikits_optimization/metadata.xml
+++ /dev/null
@@ -1,11 +0,0 @@
-<?xml version="1.0" encoding="UTF-8"?>
-<!DOCTYPE pkgmetadata SYSTEM "http://www.gentoo.org/dtd/metadata.dtd">
-<pkgmetadata>
-  <maintainer type="project">
-    <email>sci@gentoo.org</email>
-    <name>Gentoo Science Project</name>
-  </maintainer>
-  <upstream>
-    <remote-id type="pypi">scikits.optimization</remote-id>
-  </upstream>
-</pkgmetadata>
diff --git a/sci-libs/scikits_optimization/scikits_optimization-0.3-r1.ebuild b/sci-libs/scikits_optimization/scikits_optimization-0.3-r1.ebuild
deleted file mode 100644
index a86a8204ee92b..0000000000000
--- a/sci-libs/scikits_optimization/scikits_optimization-0.3-r1.ebuild
+++ /dev/null
@@ -1,31 +0,0 @@
-# Copyright 1999-2020 Gentoo Authors
-# Distributed under the terms of the GNU General Public License v2
-
-EAPI=7
-
-PYTHON_COMPAT=( python3_{6,7} )
-
-inherit distutils-r1
-
-MY_P="${P/scikits_/scikits.}"
-
-DESCRIPTION="Python module for numerical optimization"
-HOMEPAGE="http://projects.scipy.org/scipy/scikits"
-SRC_URI="mirror://pypi/${PN:0:1}/scikits.optimization/${MY_P}.tar.gz"
-
-LICENSE="BSD"
-SLOT="0"
-KEYWORDS="~amd64 ~x86 ~amd64-linux ~x86-linux"
-IUSE=""
-
-RDEPEND="
-	dev-python/numpy[${PYTHON_USEDEP}]
-	sci-libs/scikits[${PYTHON_USEDEP}]"
-DEPEND="${RDEPEND}
-	dev-python/setuptools[${PYTHON_USEDEP}]"
-
-S="${WORKDIR}/${MY_P}"
-
-python_test() {
-	esetup.py test
-}