diff --git a/sci-libs/rpp/Manifest b/sci-libs/rpp/Manifest
index bb009d9a3dd18..ec3508e9c6809 100644
--- a/sci-libs/rpp/Manifest
+++ b/sci-libs/rpp/Manifest
@@ -1,3 +1,4 @@
+DIST rpp-10.1.0.tar.gz 174535964 BLAKE2B c59dba4018bbdf5281ad004f6b78baa92a23a1d49cd2dbde783f9ecb0050ddc029c7cc716c33e869e0f1d139f25ab3cecfbd4c9062336a1dc94475cfa543b27a SHA512 d94b453c7d7d0f494de0b25329370a808bba89bec0196dbcb8cc884e5afaf45ab7ed0626af931d1e0936d98887a18ff943b9120cebe6e7b1eb81032e7b83f794
 DIST rpp-6.3.3.tar.gz 56093678 BLAKE2B de0933386d7c6a3cce88a36e22c25bea0cdda766dbc9a297bb6f5271b7a310670faa2d1dd3cc56f52e2752946f930ad02c4de2680dea3456e09ca97d4fa6c520 SHA512 024211ab05d95fbe0bb960a08b083e5b777d4842dd717a6280b1de84402426f5f9016e3b258ef81042281d775bd5504b285dd06d246f4d3479ffe57e59935184
 DIST rpp-6.4.3.tar.gz 66049573 BLAKE2B cf4a31c4595e3148030a75a4c47a3bcce99002880b273fbc151948eae32639bce21126be911f18b1832d4892756b39925d79423ce455597f892fee30271f0a80 SHA512 fda88addba7a3b8ea28bcdf559a28adbf4cfd522d7071ed64c4846777a6bf1ac1143ec43719f8f83f3b948e28658a1ccbc51eccada128ddfa73aed3002506ae9
 DIST rpp-7.0.2.tar.gz 73713099 BLAKE2B 939af01b4a63c659c708b17ab603ed122d8b99fd2fbb031d4ff00733f4ff36892df6014b6311bd731593085da2657442e5b8922da3c4c6edf09faa26fc1709b4 SHA512 26810258932e4d9c7b40375792f32a792f8a1b464d922b27753ee863002b9981b3a109e7e773f937808d5bdd2b87875d408e8d4e009d6b877fd31bd0224bbb17
diff --git a/sci-libs/rpp/rpp-10.1.0.ebuild b/sci-libs/rpp/rpp-10.1.0.ebuild
new file mode 100644
index 0000000000000..a41ef783a6ee2
--- /dev/null
+++ b/sci-libs/rpp/rpp-10.1.0.ebuild
@@ -0,0 +1,104 @@
+# Copyright 1999-2026 Gentoo Authors
+# Distributed under the terms of the GNU General Public License v2
+
+EAPI=8
+
+ROCM_VERSION=${PV}
+PYTHON_COMPAT=( python3_{10..15} )
+
+inherit cmake python-any-r1 rocm toolchain-funcs
+
+DESCRIPTION="AMD ROCm Performance Primitives (RPP) high-performance computer vision library"
+HOMEPAGE="https://github.com/ROCm/rocm-libraries/tree/develop/projects/rpp"
+SRC_URI="https://github.com/ROCm/rocm-libraries/releases/download/therock-${PV%.0}/rpp.tar.gz -> rpp-${PV}.tar.gz"
+S="${WORKDIR}/rpp"
+
+LICENSE="MIT"
+SLOT="0/$(ver_cut 1-2)"
+KEYWORDS="~amd64"
+
+IUSE="cpu_flags_x86_avx2 cpu_flags_x86_fma3 cpu_flags_x86_f16c test"
+# pkgcheck warning: RequiredUseDefaults
+REQUIRED_USE="
+	cpu_flags_x86_avx2 cpu_flags_x86_fma3 cpu_flags_x86_f16c
+	${ROCM_REQUIRED_USE}
+"
+RESTRICT="!test? ( test )"
+
+# half.hpp is included by the installed rppdefs.h
+RDEPEND="
+	>=dev-libs/half-1.12.0-r1
+	dev-util/hip:${SLOT}
+	llvm-runtimes/openmp
+"
+DEPEND="${RDEPEND}"
+BDEPEND="test? ( ${PYTHON_DEPS} )"
+
+DOCS=( CHANGELOG.md README.md )
+
+pkg_setup() {
+	use test && python-any-r1_pkg_setup
+}
+
+src_prepare() {
+	# no asan libs; upstream test suite (~420 MB of data) is only used from ${S} in src_test
+	sed -e "s/COMPONENT \(asan\|test\)/COMPONENT \1 EXCLUDE_FROM_ALL/" -i CMakeLists.txt || die
+	# builds test programs against an already installed rpp, automagic OpenCV/NIfTI/libsndfile
+	cmake_comment_add_subdirectory utilities/test_suite
+	use test || cmake_comment_add_subdirectory test
+	cmake_src_prepare
+}
+
+src_configure() {
+	rocm_use_clang
+
+	local mycmakeargs=(
+		-DCMAKE_SKIP_RPATH=ON
+		-DGPU_TARGETS="$(get_amdgpu_flags)"
+		-DROCM_PATH=/usr
+		-DBACKEND=HIP
+		# audio augmentations need FFTS (bundled prebuilt libffts.a is gone, FFTS is not packaged)
+		-DRPP_AUDIO_SUPPORT=OFF
+		-DCMAKE_DISABLE_FIND_PACKAGE_FFTS=ON
+	)
+
+	cmake_src_configure
+}
+
+rpp_qa() {
+	local backend=${1} suite=${2} failed
+	local dir="${T}/qa/${backend}-${suite}"
+	mkdir -p "${dir}" || die
+	pushd "${dir}" >/dev/null || die
+	# the drivers exit non-zero on QA mismatches (checked below)
+	"${EPYTHON}" "${S}/utilities/test_suite/${backend}/run${suite}Tests.py" \
+		--qa_mode 1 --batch_size 3 |& tee qa.log
+	# the drivers only log build failures and crashes of the test programs
+	grep -qi -e "^Traceback" -e "non-zero exit status" qa.log && die "${backend} ${suite}: test programs failed"
+	local results=( QA_RESULTS_*/QA_results.txt )
+	[[ -f ${results[0]} ]] || die "${backend} ${suite}: no QA results"
+	failed=$(grep -h FAILED "${results[@]}")
+	# the random boxes come from <random> distributions; libc++ differs from the reference outputs
+	if [[ $(tc-get-cxx-stdlib) == libc++ ]]; then
+		failed=$(grep -vE "^(coarse|random_erase)_" <<<"${failed}")
+	fi
+	[[ -z ${failed} ]] || die "${backend} ${suite} QA failures:"$'\n'"${failed}"
+	popd >/dev/null || die
+}
+
+src_test() {
+	check_amdgpu
+
+	# no RPATH: use the library from the build tree, not an installed one
+	LD_LIBRARY_PATH="${BUILD_DIR}/$(get_libdir)" cmake_src_test
+
+	# upstream QA drivers build their test programs against an installed rpp
+	DESTDIR="${T}/stage" cmake_build install
+	local -x ROCM_PATH="${EPREFIX}/usr" CMAKE_PREFIX_PATH="${T}/stage/usr"
+	local -x LD_LIBRARY_PATH="${T}/stage/usr/$(get_libdir)"
+	local backend
+	for backend in HOST HIP; do
+		rpp_qa ${backend} Image
+		rpp_qa ${backend} Misc
+	done
+}