diff --git a/eclass/python-utils-r1.eclass b/eclass/python-utils-r1.eclass
index 3af3cbdb075e1..caa39813feec7 100644
--- a/eclass/python-utils-r1.eclass
+++ b/eclass/python-utils-r1.eclass
@@ -884,7 +884,7 @@ python_doheader() {
 	[[ ${EPYTHON} ]] || die 'No Python implementation set (EPYTHON is null).'
 
 	local includedir=$(python_get_includedir)
-	local d=${includedir#${EPREFIX}}
+	local d=${includedir#${ESYSROOT}}
 
 	(
 		insopts -m 0644