diff --git a/dev-python/nanobind/Manifest b/dev-python/nanobind/Manifest
index 0cd74d787a5af..e59eee81b0031 100644
--- a/dev-python/nanobind/Manifest
+++ b/dev-python/nanobind/Manifest
@@ -1,2 +1,3 @@
 DIST nanobind-2.5.0.gh.tar.gz 900479 BLAKE2B 9711cde535b6e6717477229f25e2f8abc5d1973ccd307ad1d55613ac0b288815960ece8b279a4dded47dc90e86ad4d44b216e27012120fcc7ffc26ef7711e800 SHA512 885668ee4ea9c551ccd60d2e056a90021badfeb7b358aeace184a23f9c2d34cb31a81ebe84db33fd6f15b7983dbb455d9c11f9367de091cb9b56c99d7634f9a0
 DIST nanobind-2.6.0.gh.tar.gz 905010 BLAKE2B 0d763035653fb3375a5424d875153ffd5ed33c839fe800f639866d9aeee8459a79f1472e7c724271b724bda5ce73fbd5d0327d7331110968abf5e9de030ad6ed SHA512 f8429a5f3e6e84a6ab1890086078e2f313bbf0c77c35ade3aab5d14f9d65dba36cf8ccca16c9add0d12894d085ce445bfda519a28e23bdbc359c977b185efdd5
+DIST nanobind-2.6.1.gh.tar.gz 905030 BLAKE2B 7e29ab9da53df88e9034bb35fa53ae0e4a8b25ea92f0d1480341164b62b12d4d809bd50260c05d33f0f2494dff8cc9f445199653a506a2685a531c9b347816a7 SHA512 0807866b98e3089df98d1c88474f6ac31f8ae0d1838b181c7f3462ff2b6f344026144de1b1884d2ee58c126ac275135fa1c9c58c6158647c06509d5cc20fa84e
diff --git a/dev-python/nanobind/nanobind-2.6.1.ebuild b/dev-python/nanobind/nanobind-2.6.1.ebuild
new file mode 100644
index 0000000000000..54382505da8a9
--- /dev/null
+++ b/dev-python/nanobind/nanobind-2.6.1.ebuild
@@ -0,0 +1,70 @@
+# Copyright 1999-2025 Gentoo Authors
+# Distributed under the terms of the GNU General Public License v2
+
+EAPI=8
+
+DISTUTILS_USE_PEP517=scikit-build-core
+PYTHON_COMPAT=( python3_{10..13} )
+
+inherit cmake distutils-r1
+
+DESCRIPTION="Tiny and efficient C++/Python bindings"
+HOMEPAGE="
+	https://github.com/wjakob/nanobind/
+	https://pypi.org/project/nanobind/
+"
+SRC_URI="
+	https://github.com/wjakob/nanobind/archive/refs/tags/v${PV}.tar.gz
+		-> ${P}.gh.tar.gz
+"
+
+LICENSE="BSD"
+SLOT="0"
+KEYWORDS="~amd64 ~ppc64 ~riscv"
+
+DEPEND="
+	>=dev-cpp/robin-map-1.3.0
+"
+RDEPEND="
+	${DEPEND}
+"
+BDEPEND="
+	$(python_gen_cond_dep '
+		dev-python/typing-extensions[${PYTHON_USEDEP}]
+	' 3.10)
+"
+
+EPYTEST_XDIST=1
+distutils_enable_tests pytest
+
+src_prepare() {
+	# https://github.com/scikit-build/scikit-build-core/issues/912
+	sed -i -e '/scikit-build-core/s:0\.10:0.8:' pyproject.toml || die
+	cmake_src_prepare
+	distutils-r1_src_prepare
+}
+
+src_configure() {
+	# XXX: nanobind installs a CMake config file which by default passes -Os
+	# We currently patch around it in dev-python/pyopencl. In future, we
+	# may want to add some override with Gentoo specific environment vars.
+	DISTUTILS_ARGS=(
+		-DNB_CREATE_INSTALL_RULES=ON
+		-DNB_USE_SUBMODULE_DEPS=OFF
+		-DNB_TEST=OFF
+	)
+}
+
+python_test() {
+	local mycmakeargs=(
+		-DNB_CREATE_INSTALL_RULES=OFF
+		-DNB_USE_SUBMODULE_DEPS=OFF
+		-DNB_TEST=ON
+	)
+	cmake_src_configure
+	cmake_src_compile
+
+	local -x PYTEST_DISABLE_PLUGIN_AUTOLOAD=1
+	cd "${BUILD_DIR}/tests" || die
+	epytest
+}